Herpes zoster prophylaxis with low-dose acyclovir in patients with malignant lymphoma and multiple myeloma treated with autologous stem cell transplantation

被引：6

作者：

Abbasov, Emin ^{[1
]}

Metzner, Bernd ^{[1
]}

Mueller, Thomas H. ^{[2
]}

Casper, Jochen ^{[1
]}

Kimmich, Christoph ^{[1
]}

Petershofen, Eduard K. ^{[2
]}

Renzelmann, Andrea ^{[1
]}

Rosien, Bernd ^{[1
]}

Thole, Ruth ^{[1
]}

Voss, Andreas ^{[1
]}

Koehne, Claus Henning ^{[1
]}

机构：

[1] Univ Clin, Klinikum Oldenburg, Dept Hematol & Oncol, Oldenburg, Germany

[2] Red Cross Blood Transfus Serv NSTOB, Oldenburg, Germany

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2022年 / 109卷 / 03期

关键词：

acyclovir; autologous stem-cell transplantation; herpes zoster; malignant lymphoma; multiple myeloma; prophylaxis; ANTIVIRAL PROPHYLAXIS; VIRUS INFECTION; POSTHERPETIC NEURALGIA; RISK-FACTORS; RECIPIENTS; COMPLICATIONS; REACTIVATION; PREVENTION; HEMATOLOGY; GUIDELINES;

D O I：

10.1111/ejh.13810

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Herpes zoster (HZ) is a frequent complication after autologous stem cell transplantation (ASCT). The option of zoster prophylaxis with an antiviral drug is described in the literature, but there is no consensus on the drug and the dosage. Patients and Methods We analyzed the records of 310 patients treated with ASCT who were controlled regularly regarding HZ inter alia for at least 24 months following ASCT. Since 01/2015 patients received prophylactic low-dose acyclovir (400 mg per day) during the first 12 months following discharge after ASCT (n = 107). Results Twenty percent of patients without this kind of prophylaxis and 2.8% of patients with prophylaxis developed HZ (p < .001). No patient with this prophylaxis developed HZ in the first year after ASCT, 2.8% of patients in the second year after ASCT. A prognostic factor was the kind of diagnosis: 30% of lymphoma patients and 14% of myeloma patients developed HZ in the first 24 months after ASCT without prophylaxis, but only 6.3% and 0% of patients with prophylaxis, respectively. Neither an increase of HZ cases following prophylaxis nor acyclovir refractory HZ cases were observed. Conclusions Zoster prophylaxis with low-dose acyclovir over 12 months after ASCT is effective and well tolerated.

引用

页码：298 / 304

页数：7

共 28 条

[1] Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation A Randomized Clinical Trial [J].

Bastidas, Adriana ;

de la Serna, Javier ;

El Idrissi, Mohamed ;

Oostvogels, Lidia ;

Quittet, Philippe ;

Lopez-Jimenez, Javier ;

Vural, Filiz ;

Pohlreich, David ;

Zuckerman, Tsila ;

Issa, Nicolas C. ;

Gaidano, Gianluca ;

Lee, Je-Jung ;

Abhyankar, Sunil ;

Solano, Carlos ;

Perez de Oteyza, Jaime ;

Satlin, Michael J. ;

Schwartz, Stefan ;

Campins, Magda ;

Rocci, Alberto ;

Llamas, Carlos Vallejo ;

Lee, Dong-Gun ;

Tan, Sen Mui ;

Johnston, Anna M. ;

Grigg, Andrew ;

Boeckh, Michael J. ;

Campora, Laura ;

Lopez-Fauqued, Marta ;

Heineman, Thomas C. ;

Stadtmauer, Edward A. ;

Sullivan, Keith M. ;

Alonso Alonso, Aranzazu ;

Anagnostopoulos, Achilles ;

Andreadis, Charalambos ;

Angelopoulou, Maria ;

Anttila, Veli-Jukka ;

Aoun, Mickael ;

Barista, Ibrahim ;

Berkahn, Leanne ;

Bloor, Adrian J. C. ;

Broady, Raewyn ;

Brossart, Peter ;

Buadi, Francis K. ;

Bulabois, Claude-Eric ;

Cantin, Guy ;

Cellini, Claudia ;

Chandrasekar, Pranatharthi Haran ;

Chauncey, Thomas ;

Cuneo, Antonio ;

Dadwal, Sanjeet Singh ;

Dickinson, Michael .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (02) :123-133

[2] Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue [J].

Bilgrami, S ;

Chakraborty, NG ;

Rodriguez-Pinero, F ;

Khan, AM ;

Feingold, JM ;

Bona, RD ;

Edwards, RL ;

Dorsky, D ;

Clive, J ;

Mukherji, B ;

Tutschka, PJ .

BONE MARROW TRANSPLANTATION, 1999, 23 (05) :469-474

[3] Immunogenicity of Inactivated Varicella Zoster Vaccine in Autologous Hematopoietic Stem Cell Transplant Recipients and Patients With Solid or Hematologic Cancer [J].

Boeckh, Michael J. ;

Arvin, Ann M. ;

Mullane, Kathleen M. ;

Camacho, Luis H. ;

Winston, Drew J. ;

Morrison, Vicki A. ;

Hurtado, Kimberly ;

Hall, Jessie Durrand ;

Pang, Lei ;

Su, Shu-Chih ;

Kaplan, Susan S. ;

Annunziato, Paula W. ;

Popmihajlov, Zoran .

OPEN FORUM INFECTIOUS DISEASES, 2020, 7 (07)

[4] Prophylaxis, diagnosis and therapy of infections in patients undergoing high-dose chemotherapy and autologous haematopoietic stem cell transplantation. 2020 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) [J].

Christopeit, Maximilian ;

Schmidt-Hieber, Martin ;

Sprute, Rosanne ;

Buchheidt, Dieter ;

Hentrich, Marcus ;

Karthaus, Meinolf ;

Penack, Olaf ;

Ruhnke, Markus ;

Weissinger, Florian ;

Cornely, Oliver A. ;

Maschmeyer, Georg .

ANNALS OF HEMATOLOGY, 2021, 100 (02) :321-336

[5] Recombinant Zoster Vaccine Significantly Reduces the Impact on Quality of Life Caused by Herpes Zoster in Adult Autologous Hematopoietic Stem Cell Transplant Recipients: A Randomized Placebo-Controlled Trial (ZOE-HSCT) [J].

Curran, Desmond ;

Matthews, Sean ;

Rowley, Scott D. ;

Young, Jo-Anne H. ;

Bastidas, Adriana ;

Anagnostopoulos, Achilles ;

Barista, Ibrahim ;

Chandrasekar, Pranatharthi Haran ;

Dickinson, Michael ;

El Idrissi, Mohamed ;

Heras, Inmaculada ;

Milliken, Samuel T. ;

Monserrat Coll, Jorge ;

Navarro Matilla, Maria Belen ;

Oostvogels, Lidia ;

Piatkowska-Jakubas, Beata ;

Quiel, Dimas ;

Sabry, Waleed ;

Schwartz, Stefan ;

Selleslag, Dominik L. D. ;

Sullivan, Keith M. ;

Theunissen, Koen ;

Yegin, Zeynep Arzu ;

Yeh, Su-Peng ;

Zaja, Francesco ;

Szer, Jeff ;

Sauboin, Christophe ;

Marcos, Camelia ;

Heineman, Thomas C. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (12) :2474-2481

[6] One-year acyclovir prophylaxis for preventing varicella-zoster virus disease after hematopoietic cell transplantation: no evidence of rebound varicella-zoster virus disease after drug discontinuation [J].

Erard, Veronique ;

Guthrie, Katherine A. ;

Varley, Cara ;

Heugel, Judson ;

Wald, Anna ;

Flowers, Mary E. D. ;

Corey, Lawrence ;

Boeckh, Michael .

BLOOD, 2007, 110 (08) :3071-3077

[7] Predicting risk factors for varicella zoster virus infection and postherpetic neuralgia after hematopoietic cell transplantation using ordered logistic regression analysis [J].

Kanbayashi, Yuko ;

Matsumoto, Yosuke ;

Kuroda, Junya ;

Kobayashi, Tsutomu ;

Horiike, Shigeo ;

Hosokawa, Toyoshi ;

Taniwaki, Masafumi .

ANNALS OF HEMATOLOGY, 2017, 96 (02) :311-315

[8] Risk Factors for Herpes Zoster: A Systematic Review and Meta-analysis [J].

Kawai, Kosuke ;

Yawn, Barbara P. .

MAYO CLINIC PROCEEDINGS, 2017, 92 (12) :1806-1821

[9] Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus and varicella zoster virus diseases after autologous hematopoietic stem cell transplantation [J].

Kawamura, Koji ;

Hayakawa, Jin ;

Akahoshi, Yu ;

Harada, Naonori ;

Nakano, Hirofumi ;

Kameda, Kazuaki ;

Ugai, Tomotaka ;

Wada, Hidenori ;

Yamasaki, Ryoko ;

Ishihara, Yuko ;

Sakamoto, Kana ;

Ashizawa, Masahiro ;

Sato, Miki ;

Terasako-Saito, Kiriko ;

Kimura, Shun-ichi ;

Kikuchi, Misato ;

Nakasone, Hideki ;

Yamazaki, Rie ;

Kanda, Junya ;

Kako, Shinichi ;

Tanihara, Aki ;

Nishida, Junji ;

Kanda, Yoshinobu .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2015, 102 (02) :230-237

[10] Low-dose Acyclovir is Effective for Prevention of Herpes Zoster in Myeloma Patients Treated with Bortezomib: A Report from the Korean Multiple Myeloma Working Party (KMMWP) Retrospective Study [J].

Kim, Seok Jin ;

Kim, Kihyun ;

Do, Young Rok ;

Bae, Sung Hwa ;

Yang, Deok-Hwan ;

Lee, Je-Jung .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 41 (03) :353-357

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