Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases

被引：19

作者：

Gan, Zhending ^{[1
]}

Zhang, Meiyu ^{[2
]}

Xie, Donghui ^{[3
]}

Wu, Xiaoyan ^{[1
,4
]}

Hong, Changming ^{[1
]}

Fu, Jian ^{[1
]}

Fan, Lijuan ^{[1
]}

Wang, Shengyi ^{[4
]}

Han, Sufang ^{[1
]}

机构：

[1] South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China

[2] Guangdong Polytech Sci & Trade, Coll Anim Sci & Technol, Guangzhou, Peoples R China

[3] Nanchang Acad Agr Sci, Nanchang, Jiangxi, Peoples R China

[4] Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Key Lab Vet Pharmaceut Dev, Minist Agr & Rural Affairs, Lanzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

glycine; macrophage; NF-kappa B; miRNA; inflammation; ISCHEMIA-REPERFUSION INJURY; NF-KAPPA-B; INSULIN-RESISTANCE; ADIPOSE-TISSUE; SPINAL NEURONS; KUPFFER CELLS; TNF-ALPHA; METABOLISM; INHIBITION; SERINE;

D O I：

10.3389/fimmu.2021.762564

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Accumulating evidences support that amino acids direct the fate decision of immune cells. Glycine is a simple structural amino acid acting as an inhibitory neurotransmitter. Besides, glycine receptors as well as glycine transporters are found in macrophages, indicating that glycine alters the functions of macrophages besides as an inhibitory neurotransmitter. Mechanistically, glycine shapes macrophage polarization via cellular signaling pathways (e.g., NF-kappa B, NRF2, and Akt) and microRNAs. Moreover, glycine has beneficial effects in preventing and/or treating macrophage-associated diseases such as colitis, NAFLD and ischemia-reperfusion injury. Collectively, this review highlights the conceivable role of glycinergic signaling for macrophage polarization and indicates the potential application of glycine supplementation as an adjuvant therapy in macrophage-associated diseases.

引用

页数：10

共 114 条

[11] Glycine suppresses TNF-alpha-induced activation of NF-κB in differentiated 3T3-L1 adipocytes [J].

Blancas-Flores, Gerardo ;

Alarcon-Aguilar, Francisco J. ;

Garcia-Macedo, Rebeca ;

Almanza-Perez, Julio C. ;

Flores-Saenz, Jose L. ;

Roman-Ramos, Ruben ;

Ventura-Gallegos, Jose L. ;

Kumate, Jesus ;

Zentella-Dehesa, Alejandro ;

Cruz, Miguel .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 689 (1-3) :270-277

[12] The Inhibitory Neurotransmitter Glycine Modulates Macrophage Activity by Activation of Neutral Amino Acid Transporters [J].

Carmans, Sofie ;

Hendriks, Jerome J. A. ;

Thewissen, Kristof ;

Van den Eynden, Jimmy ;

Stinissen, Piet ;

Rigo, Jean-Michel ;

Hellings, Niels .

JOURNAL OF NEUROSCIENCE RESEARCH, 2010, 88 (11) :2420-2430

[13] Prophylactic Glycine Administration Attenuates Pancreatic Damage and Inflammation in Experimental Acute Pancreatitis [J].

Ceyhan, G. O. ;

Timm, A. -K. ;

Bergmann, F. ;

Guenther, A. ;

Aghdassi, A. A. ;

Demir, I. E. ;

Mayerle, J. ;

Kern, M. ;

Lerch, M. M. ;

Buechler, M. W. ;

Friess, H. ;

Schemmer, P. .

PANCREATOLOGY, 2011, 11 (01) :57-67

[14] Glycine confers neuroprotection through microRNA-301a/PTEN signaling [J].

Chen, Juan ;

Zhuang, Yang ;

Zhang, Zhi-Feng ;

Wang, Shu ;

Jin, Ping ;

He, Chunjiang ;

Hu, Peng-Chao ;

Wang, Ze-Fen ;

Li, Zhi-Qiang ;

Xia, Guang-Ming ;

Li, Gang ;

Wang, Yuan ;

Wan, Qi .

MOLECULAR BRAIN, 2016, 9

[15] Serine Supports IL-1β Production in Macrophages Through mTOR Signaling [J].

Chen, Siyuan ;

Xia, Yaoyao ;

He, Fang ;

Fu, Jian ;

Xin, Zhongquan ;

Deng, Baichuan ;

He, Liuqin ;

Zhou, Xihong ;

Ren, Wenkai .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[16] Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway [J].

Chen, Zhong-Jun ;

Zhao, Xu-Sheng ;

Fan, Tie-Ping ;

Qi, Heng-Xu ;

Li, Di .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 14 :2021-2031

[17] Participation of the IKK-α/β complex in the inhibition of the TNF-α/NF-kB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes [J].

Contreras-Nunez, Erika ;

Blancas-Flores, Gerardo ;

Cruz, Miguel ;

Cesar Almanza-Perez, Julio ;

Gomez-Zamudio, Jaime H. ;

Luis Ventura-Gallegosc, Jose ;

Zentella-Dehesa, Alejandro ;

Roberto-Lazzarini ;

Roman-Ramos, Ruben ;

Javier Alarcon-Aguilar, Francisco .

BIOMEDICINE & PHARMACOTHERAPY, 2018, 102 :120-131

[18] INHIBITION OF SPINAL NEURONES BY GLYCINE [J].

CURTIS, DR ;

HOSLI, L ;

JOHNSTON, GA .

NATURE, 1967, 215 (5109) :1502-&

[19] Kupffer Cells in the Liver [J].

Dixon, Laura J. ;

Barnes, Mark ;

Tang, Hui ;

Pritchard, Michele T. ;

Nagy, Laura E. .

COMPREHENSIVE PHYSIOLOGY, 2013, 3 (02) :785-797

[20] NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration [J].

Dorrington, Michael G. ;

Fraser, Iain D. C. .

FRONTIERS IN IMMUNOLOGY, 2019, 10

← 1 2 3 4 5 6 7 8 9 10 →