Impaired human hippocampal neurogenesis after treatment for central nervous system

被引：218

作者：

Monje, Michelle L.

Vogel, Hannes

Masek, Marilyn

Ligon, Keith L.

Fisher, Paul G.

Palmer, Theo D.

机构：

[1] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[3] Stanford Univ Hosp & Clin, Dept Pathol, Stanford, CA USA

[4] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[5] Childrens Hosp Boston, Dept Pathol, Boston, MA USA

[6] Stanford Univ Hosp & Clin, Dept Neurol, Stanford, CA USA

[7] Stanford Univ Hosp & Clin, Dept Neurosurg, Stanford, CA USA

来源：

ANNALS OF NEUROLOGY | 2007年 / 62卷 / 05期

关键词：

D O I：

10.1002/ana.21214

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects of cancer treatments such as cranial radiation and chemotherapy on human hippocampal neurogenesis remain unknown. In this study, we examine neuropathological markers of neurogenesis and inflammation in the human hippocampus after treatment for acute myelogenous leukemia or medulloblasroma. We demonstrate a persistent radiation-induced microglial inflammation that is accompanied by nearly complete inhibition of neurogenesis after cancer treatment. These findings are consistent with preclinical animal studies and suggest potential therapeutic strategies.

引用

页码：515 / 520

页数：6

共 22 条

[1] Pathogenesis of cognitive decline following therapeutic irradiation for head and neck tumors [J].