Four new megastigmane glycosides from the leaves of Eucommia ulmoides Oliver

被引：7
|
作者：
Yan, Jian-Kun [1 ,3 ]
Shi, Xu-Liu [1 ,2 ]
Donkor, Paul Owusu [1 ,2 ]
Ding, Li-Qin [1 ,2 ]
Qiu, Feng [1 ,2 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 300193, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
[3] Agr Univ Hebei, Coll Sci & Technol, Cangzhou 061100, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2018年 / 27卷
基金：
美国国家科学基金会;
关键词：
Leaves of Eucommia ulmoides Oliver; Megastigmane glycosides; ACE; Eucomegastigsides;
D O I：
10.1016/j.phytol.2018.07.031
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new megastigmane glycosides, eucomegastigsides E-1 (1), eucomegastigsides E-2 (2), eucomegastigsides F-1 (3), and eucomegastigsides F-2 (4) were isolated from the leaves of Eucommia ulmoides Oliver. Their structures were elucidated based on extensive spectroscopic analysis and their absolute configurations were determined by comparison of experimental optical rotation (OR) to DFT calculations. In addition, compounds 1-4 were evaluated for their ACE (Angiotensin Converting Enzyme) inhibitory activities using HPLC. All compounds showed moderate inhibitory effects on ACE.
引用
收藏
页码：208 / 213
页数：6
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