Construction of the highly oxidized bicyclo[3.2.1]octane CD ring system of aconitine via a late stage enyne cycloisomerization

被引：12

作者：

Zhou, Xiao-Han

Liu, Ying

Zhou, Rui-Jie

Song, Hao ^{[1
]}

Liu, Xiao-Yu

Qin, Yong ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug,Educ Minist, Chengdu 610041, Sichuan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 86期

基金：

中国国家自然科学基金;

关键词：

WAGNER-MEERWEIN REARRANGEMENT; DITERPENOID ALKALOIDS; C-19-DITERPENOID ALKALOIDS; TALATISAMINE; STRATEGY; ATISINE;

D O I：

10.1039/c8cc06819d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy for synthesizing the highly oxidized bicyclo[3.2.1]octane CD rings of aconitine is reported. The key features of the synthesis include a ring-closing metathesis to form the C-ring as well as the application of a ruthenium-catalysed enyne cycloisomerization to assemble the bridged CD ring system of aconitine.

引用

页码：12258 / 12261

页数：4

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