Uncatalysed domino reaction in hexafluoroisopropanol:: A simple protocol for the synthesis of tetrahydroquinoline derivatives

被引：25

作者：

Di Salvo, A ^{[1
]}

Spanedda, MV ^{[1
]}

Ourévitch, M ^{[1
]}

Crousse, B ^{[1
]}

Bonnet-Delpon, D ^{[1
]}

机构：

[1] Ctr Etud Pharmaceut, BioCIS, F-92296 Chatenay Malabry, France

来源：

SYNTHESIS-STUTTGART | 2003年 / 14期

关键词：

Diels-Alder reactions; domino reactions; cycloaddition; nucleophilic additions; 1,1,1,3,3,3-hexafluoro-2-propanol;

D O I：

10.1055/s-2003-41074

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of tetrahydroquinolines were synthesised in excellent yields through a domino reaction performed in hexafluoropropanol, starting from anilines and enol ethers and in the absence of Lewis acid catalysis. This solvent was shown to promote the nucleophilic addition of anilines to enol ethers as well as the aza-Diels-Alder reaction.

引用

页码：2231 / 2235

页数：5

共 27 条

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