A role for genetic predisposition in subglottic stenosis

被引:3
作者
Pizzuto, M
Donaldson, D
Brodsky, L
机构
[1] Childrens Hosp Buffalo, Dept Otolaryngol, Buffalo, NY 14221 USA
[2] Childrens Hosp Buffalo, Dept Pediat Otolaryngol, Buffalo, NY 14221 USA
关键词
subglottic stenosis; elliptical cricoid;
D O I
10.1016/S0165-5876(98)00073-1
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
We present the development of ASGS in two of three premature male triplets; the affected infants were monozygotic, while the unaffected triplet was dizygotic. All three shared remarkably similar risk factor profiles. There is suggested the existence of a genetic factor or factors which may predispose certain infants to the development of ASGS. The expression of such genetic influence may be expressed through the a priori presence of CSGS or other genetically based mechanisms including abnormal cartilage growth or development, specific patterns of chondral or mucosal injury, the action of specific growth factors, or the effects of autoimmune or inflammatory mediators. We propose that genetic predisposition be considered a possible risk factor in the development of subglottic stenosis.
引用
收藏
页码:279 / 284
页数:6
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