Total Synthesis of Two Pyrrole Spiroketal Alkaloids: Pollenopyrroside A and Capparisine B

被引：12

作者：

Cao, Zhi ^{[1
]}

Li, Yueqing ^{[1
]}

Wang, Shisheng ^{[1
]}

Guo, Xiuhan ^{[1
]}

Wang, Liu ^{[1
]}

Zhao, Weijie ^{[1
]}

机构：

[1] Dalian Univ Technol, Sch Pharmaceut Sci & Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

SYNLETT | 2015年 / 26卷 / 07期

关键词：

alkaloids; spiroketals; natural products; total synthesis; microwave-assisted reaction; STEREOSELECTIVE-SYNTHESIS; PROTECTING GROUPS; CARBOHYDRATE; ACORTATARINS; DEPROTECTION;

D O I：

10.1055/s-0034-1380172

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pollenopyrroside A and capparisine B, two diastereoisomers of pyrrole spiroketal alkaloids isolated from Brassica campestris pollen and Capparis spinosa, were synthesized by an improved microwave-assisted bishydroxymethylation of pyrrole and acid-catalyzed spirocyclization as key steps with total yields of 2.7 and 8.8%, respectively.

引用

页码：921 / 926

页数：6

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