Inflammation: A Network in the Pathogenesis of Status Epilepticus

被引：35
作者：
Wang, Ming [1 ]
Chen, Yinghui [2 ]
机构：
[1] Fudan Univ, Jinshan Hosp, Dept Neurol, Shanghai, Peoples R China
[2] Fudan Univ, Huashan Hosp North, Dept Neurol, Shanghai, Peoples R China
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2018年 / 11卷
关键词：
status epilepticus; inflammation; cytokines; inflammatory signaling pathway; NF-kappa B; NECROSIS-FACTOR-ALPHA; P2X7; RECEPTOR; INHIBITION; INFECTION; EPILEPSY; CYCLOOXYGENASE-2; ACTIVATION; SEIZURES; PATHWAY; WINDOW;
D O I：
10.3389/fnmol.2018.00341
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Status epilepticus (SE) is an abnormally prolonged or recurrent epileptic seizure that is a serious, life-threatening medical emergency. Notably, it requires prompt and aggressive treatment. SE is characterized by high mortality and morbidity. However, its pathogenesis remains unclear. Numerous studies of SE have reported widespread brain inflammation, suggesting that inflammation plays a vital role in the occurrence and development of SE. This mini review article reviews the current knowledge with regard to the role of inflammation in SE.
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页数：5
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