68Ga-PSMA ligand PET/CT in patients with prostate cancer: How we review and report

被引:160
作者
Rauscher, Isabel [1 ,2 ,3 ]
Maurer, Tobias [2 ,4 ]
Fendler, Wolfgang P. [2 ,5 ]
Sommer, Wieland H. [2 ,6 ]
Schwaiger, Markus [1 ,2 ,3 ]
Eiber, Matthias [1 ,2 ,3 ]
机构
[1] Tech Univ Munich, Dept Nucl Med, Klinikum Rechts Isar, Ismaninger Str 22, D-81675 Munich, Germany
[2] Clin Canc Ctr Munich CCM, Munich, Germany
[3] German Canc Consortium DKTK, Heidelberg, Germany
[4] Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Ismaninger Str 22, D-81675 Munich, Germany
[5] Univ Munich, Dept Nucl Med, Marchioninistr 15, D-81377 Munich, Germany
[6] Univ Munich, Dept Clin Radiol, Grosshadern Campus,Marchioninistr 15, D-81377 Munich, Germany
关键词
Prostate cancer; Prostate specific membrane antigen; Positron emission tomography; GA-68-LABELED PSMA LIGAND; MEMBRANE ANTIGEN; BIOCHEMICAL RECURRENCE; RADICAL PROSTATECTOMY; LYMPH-NODES; HBED-CC; DIAGNOSIS; EXPRESSION; CARCINOMA; TOMOGRAPHY;
D O I
10.1186/s40644-016-0072-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Recently, positron emission tomography (PET) imaging using PSMA-ligands has gained high attention as a promising new radiotracer in patients with prostate cancer (PC). Several studies promise accurate staging of primary prostate cancer and restaging after biochemical recurrence with Ga-68-PSMA ligand Positron emission tomography/computed tomography (PET/CT). However, prospective trials and clinical guidelines for this new technique are still missing. Therefore, we summarized our experience with Ga-68-PSMA ligand PET/CT examinations in patients with primary PC and biochemical recurrence. It focuses on the technical and logistical aspects of Ga-68-PSMA ligand PET/CT examination as well as on the specific background for image reading discussing also potential pitfalls. Further, it includes relevant issues on free-text as well as structured reporting used in daily clinical routine.
引用
收藏
页数:10
相关论文
共 51 条
[1]   Comparison of PET/CT and PET/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience [J].
Afshar-Oromieh, A. ;
Haberkorn, U. ;
Schlemmer, H. P. ;
Fenchel, M. ;
Eder, M. ;
Eisenhut, M. ;
Hadaschik, B. A. ;
Kopp-Schneider, A. ;
Roethke, M. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 (05) :887-897
[2]   PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions [J].
Afshar-Oromieh, A. ;
Malcher, A. ;
Eder, M. ;
Eisenhut, M. ;
Linhart, H. G. ;
Hadaschik, B. A. ;
Holland-Letz, T. ;
Giesel, F. L. ;
Kratochwil, C. ;
Haufe, S. ;
Haberkorn, U. ;
Zechmann, C. M. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 (04) :486-495
[3]   The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer [J].
Afshar-Oromieh, Ali ;
Avtzi, Eleni ;
Giesel, Frederik L. ;
Holland-Letz, Tim ;
Linhart, Heinz G. ;
Eder, Matthias ;
Eisenhut, Michael ;
Boxler, Silvan ;
Hadaschik, Boris A. ;
Kratochwil, Clemens ;
Weichert, Wilko ;
Kopka, Klaus ;
Debus, Juergen ;
Haberkorn, Uwe .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 (02) :197-209
[4]   Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer [J].
Afshar-Oromieh, Ali ;
Zechmann, Christian M. ;
Malcher, Anna ;
Eder, Matthias ;
Eisenhut, Michael ;
Linhart, Heinz G. ;
Holland-Letz, Tim ;
Hadaschik, Boris A. ;
Giesel, Frederik L. ;
Debus, Juergen ;
Haberkorn, Uwe .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 (01) :11-20
[5]  
[Anonymous], CLIN NUCL MED
[6]  
[Anonymous], EUROPEAN UROLOGY S
[7]  
[Anonymous], 2016, EUR UROL
[8]  
[Anonymous], RECENT RESULTS CANC
[9]   Paget bone disease demonstrated on 68Ga-PSMA ligand PET/CT [J].
Artigas, C. ;
Alexiou, J. ;
Garcia, C. ;
Wimana, Z. ;
Otte, F-X. ;
Gil, T. ;
Van Velthoven, R. ;
Flamen, P. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2016, 43 (01) :195-196
[10]   Radionuclide and hybrid imaging of recurrent prostate cancer [J].
Beer, Ambros J. ;
Eiber, Matthias ;
Souvatzoglou, Michael ;
Schwaiger, Markus ;
Krause, Bernd Joachim .
LANCET ONCOLOGY, 2011, 12 (02) :181-191