Aplidiopsamine A, an Antiplasmodial Alkaloid from the Temperate Australian Ascidian, Aplidiopsis confluata

被引：58

作者：

Carroll, Anthony R. ^{[1
,2
]}

Duffy, Sandra ^{[2
]}

Avery, Vicky M. ^{[2
]}

机构：

[1] Griffith Univ, Environm Futures Ctr, Gold Coast, Qld 4222, Australia

[2] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 23期

关键词：

NATURAL-PRODUCTS; INDOLE ALKALOIDS; A-C; PYRROLNITRIN; MARINE; DERIVATIVES;

D O I：

10.1021/jo101695v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A polyaromatic alkaloid, aplidiopsamine A was isolated from the temperate Australian ascidian, Aplidiopsis confluata, and its structure was determined from interpretation of mass, 1D and 2D NMR spectra. Aplidiopsamine A is the first alkaloid to possess the tricyclic aromatic substructure 3H-pyrrolo[2,3-c]quinoline conjugated to an adenine. Aplidiopsamine A exhibited significant inhibition of growth of chloroquine resistant and sensitive strains of the malaria parasite, Plasmodium falciparum, and minimal toxicity toward human cells.

引用

页码：8291 / 8294

页数：4

共 20 条

[1] A photochemical approach to pyridopyrroloquinoline derivatives as new potential anticancer agents
Aragon, PJ
Yapi, AD
Pinguet, F
Chezal, JM
Teulade, JC
Chapat, JP
Blache, Y
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (06) : 659 - 663
[2] Marine natural products
Blunt, John W.
Copp, Brent R.
Munro, Murray H. G.
Northcote, Peter T.
Prinsep, Michele R.
[J]. NATURAL PRODUCT REPORTS, 2010, 27 (02) : 165 - 237
[3] Citronamides A and B, Tetrapeptides from the Australian Sponge Citronia astra
Carroll, Anthony R.
Duffy, Sandra
Avery, Vicky M.
[J]. JOURNAL OF NATURAL PRODUCTS, 2009, 72 (04): : 764 - 768
[4] Leptoclinidamines A-C, Indole Alkaloids from the Australian Ascidian Leptoclinides durus
Carroll, Anthony R.
Avery, Vicky M.
[J]. JOURNAL OF NATURAL PRODUCTS, 2009, 72 (04): : 696 - 699
[5] C-13 NMR-STUDIES OF METHYLNUCLEOSIDES
CHANG, CJ
ASHWORTH, DJ
CHERN, LJ
GOMES, JD
LEE, CG
MOU, PW
NARAYAN, R
[J]. ORGANIC MAGNETIC RESONANCE, 1984, 22 (11): : 671 - 675
[6] El-Banna N, 1998, J APPL MICROBIOL, V85, P69
[7] Flinderoles A-C: Antimalarial Bis-indole Alkaloids from Flindersia Species
Fernandez, Liza S.
Buchanan, Malcolm S.
Carroll, Anthony R.
Feng, Yun Jiang
Quinn, Ronald J.
Avery, Vicky M.
[J]. ORGANIC LETTERS, 2009, 11 (02) : 329 - 332
[8] Antimalarial Natural Products of Marine and Freshwater Origin
Gademann, Karl
Kobylinska, Joanna
[J]. CHEMICAL RECORD, 2009, 9 (03) : 187 - 198
[9] PYRROLNITRIN FROM MYXOCOCCUS-FULVUS (MYXOBACTERALES)
GERTH, K
TROWITZSCH, W
WRAY, V
HOFLE, G
IRSCHIK, H
REICHENBACH, H
[J]. JOURNAL OF ANTIBIOTICS, 1982, 35 (08) : 1101 - 1103
[10] The manzamines as an example of the unique structural classes available for the discovery and optimization of infectious disease controls based on marine natural products
Hamann, Mark T.
[J]. CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (06) : 653 - 660

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