Aplidiopsamine A, an Antiplasmodial Alkaloid from the Temperate Australian Ascidian, Aplidiopsis confluata

被引：60

作者：

Carroll, Anthony R. ^{[1
,2
]}

Duffy, Sandra ^{[2
]}

Avery, Vicky M. ^{[2
]}

机构：

[1] Griffith Univ, Environm Futures Ctr, Gold Coast, Qld 4222, Australia

[2] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 23期

关键词：

NATURAL-PRODUCTS; INDOLE ALKALOIDS; A-C; PYRROLNITRIN; MARINE; DERIVATIVES;

D O I：

10.1021/jo101695v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A polyaromatic alkaloid, aplidiopsamine A was isolated from the temperate Australian ascidian, Aplidiopsis confluata, and its structure was determined from interpretation of mass, 1D and 2D NMR spectra. Aplidiopsamine A is the first alkaloid to possess the tricyclic aromatic substructure 3H-pyrrolo[2,3-c]quinoline conjugated to an adenine. Aplidiopsamine A exhibited significant inhibition of growth of chloroquine resistant and sensitive strains of the malaria parasite, Plasmodium falciparum, and minimal toxicity toward human cells.

引用

页码：8291 / 8294

页数：4

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