Monocyte chemoattractant protein 1-2518 A/G polymorphism and susceptibility to type 2 diabetes in a Chinese population

Background: Hyperglycemia could accelerate monocyte chemoattractant protein 1 (MCP-1) production in monocytes and vascular endothelial cells. Recently, a genetic polymorphism (-2518 A/G) located in MCP-1 gene promoter has been found that could influence the expression of MCP-1. A large cohort study of Caucasians reported that MCP-1 G-2518 gene variant was negatively correlated with the prevalence of insulin resistance and type 2 diabetes. However, it is unclear whether this polymorphism is associated with type 2 diabetes in Han Chinese. Methods: We conducted a population-based case-control study of 416 type 2 diabetes cases and 416 controls. Results: Compared with the wild genotype AA, MCP-1 G-2518 gene variant could significantly decrease the prevalence of type 2 diabetes in Han Chinese (adjusted OR=0.49.95% CI 0.32-0.77, P<0.0001). The results of stratified analyses indicated that a decreased risk of type 2 diabetes related with variant genotypes was evident in younger participants (age <= 50) (adjusted OR=0.35, 95% CI 0.20-0.61, P<0.0001), and similar results were observed in males (adjusted OR=0.37, 95% CI 0.21-0.66, P=0.001) and urban participants (adjusted OR=0.35, 95% CI 0.21-0.58, P<0.0001). In addition, a statistically significant difference was observed between MCP-1-2518 A/G polymorphism and waist to hip ratio. Conclusions: Our present pilot study indicated that MCP-1 G-2518 gene variant could significantly decrease the risk of type 2 diabetes in a Chinese population. (C) 2010 Elsevier B.V. All rights reserved.