Feasibility and safety of a 6-month exercise program to increase bone and muscle strength in children with juvenile idiopathic arthritis

被引：27

作者：

Houghton, Kristin M. ^{[1
,2
]}

Macdonald, Heather M. ^{[3
,4
]}

McKay, Heather A. ^{[3
,4
,5
]}

Guzman, Jaime ^{[1
,2
]}

Duffy, Ciaran ^{[6
,7
]}

Tucker, Lori ^{[1
,2
]}

机构：

[1] British Columbia Childrens Hosp, Div Rheumatol, K4-123 ACB,4480 Oak St, Vancouver, BC V6H 3V4, Canada

[2] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada

[3] Univ British Columbia, Dept Family Practice, Vancouver, BC, Canada

[4] Vancouver Coastal Hlth Res Inst, Ctr Hip Hlth & Mobil, Vancouver, BC, Canada

[5] Univ British Columbia, Dept Orthopaed, Vancouver, BC, Canada

[6] Childrens Hosp Eastern Ontario, Dept Pediat, Div Rheumatol, Ottawa, ON, Canada

[7] Univ Ottawa, Ottawa, ON, Canada

来源：

PEDIATRIC RHEUMATOLOGY | 2018年 / 16卷

基金：

加拿大健康研究院;

关键词：

Exercise; Physical activity; Juvenile arthritis; Muscle; Bone; RANDOMIZED CONTROLLED-TRIAL; PHYSICAL-ACTIVITY QUESTIONNAIRE; RHEUMATOID-ARTHRITIS; OLDER CHILDREN; ADOLESCENTS; HEALTH; MASS; INTERVENTION; PARTICIPATION; ASSOCIATIONS;

D O I：

10.1186/s12969-018-0283-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BackgroundArthritis in childhood can be associated with muscle weakness around affected joints, low bone mass and low bone strength. Exercise is recognized as an important part of management of children with juvenile idiopathic arthritis (JIA) but the exercise prescription to best promote bone and muscle health is unknown. We therefore aimed to: 1. assess feasibility and safety of a 6-month home- and group-based exercise program for children with JIA; 2. estimate the effect of program participation on bone mass and strength, muscle function and clinical outcomes and 3. determine if any positive changes in bone and muscle outcomes are maintained 6months later.MethodsWe recruited 24 children with JIA who were part of the Linking Exercise, Physical Activity and Pathophysiology in Childhood Arthritis (LEAP) study to participate in a 6-month home-based exercise program involving jumping and handgrip exercises, resistance training and one group exercise session per month. We assessed lumbar spine bone mass (dual energy X-ray absorptiometry), distal tibia and radius bone microarchitecture and strength (high-resolution peripheral quantitative computed tomography), muscle function (jumping mechanography, dynamometry) and clinical outcomes (joint assessment, function, health-related quality of life) at baseline, 6- and 12-months. Adherence was assessed using weekly activity logs.ResultsThirteen children completed the 6-month intervention. Participants reported 9 adverse events and post-exercise pain was rare (0.4%). Fatigue improved, but there were no other sustained improvements in muscle, bone or clinical outcomes. Adherence to the exercise program was low (47%) and decreased over time.ConclusionChildren with JIA safely participated in a home-based exercise program designed to enhance muscle and bone strength. Fatigue improved, which may in turn facilitate physical activity participation. Prescribed exercise posed adherence challenges and efforts are needed to address facilitators and barriers to participation in and adherence to exercise programs among children with JIA.Trial registrationData of the children with JIA are from the LEAP study (Canadian Institutes of Health Research (CIHR; GRANT# 107535). http://www.leapjia.com/

引用

页数：12

共 49 条

[1]

[Anonymous], 2010, DIETARY REFERENCE IN

[2] Internet Program for Physical Activity and Exercise Capacity in Children With Juvenile Idiopathic Arthritis: A Multicenter Randomized Controlled Trial [J].

Armbrust, Wineke ;

Bos, G. J. F. Joyce ;

Wulffraat, Nico M. ;

van Brussel, Marco ;

Cappon, Jeannette ;

Dijkstra, Pieter U. ;

Geertzen, Jan H. B. ;

Legger, G. Elizabeth ;

van Rossum, Marion A. J. ;

Sauer, Pieter J. J. ;

Lelieveld, Otto T. H. M. .

ARTHRITIS CARE & RESEARCH, 2017, 69 (07) :1040-1049

[3] Fatigue in patients with Juvenile Idiopathic Arthritis: relationship to perceived health, physical health, self-efficacy, and participation [J].

Armbrust, Wineke ;

Lelieveld, Otto H. T. M. ;

Tuinstra, Jolanda ;

Wulffraat, Nico M. ;

Bos, G. J. F. Joyce ;

Cappon, Jeannette ;

van Rossum, Marion A. J. ;

Sauer, Pieter J. J. ;

Hagedoorn, Mariet .

PEDIATRIC RHEUMATOLOGY, 2016, 14

[4] Design and acceptance of Rheumates@Work, a combined internet-based and in person instruction model, an interactive, educational, and cognitive behavioral program for children with juvenile idiopathic arthritis [J].

Armbrust, Wineke ;

Bos, Joyce J. F. J. ;

Cappon, Jeannette ;

van Rossum, Marion A. J. J. ;

Sauer, Pieter J. J. ;

Wulffraat, Nico ;

van Wijnen, Veera K. ;

Lelieveld, Otto T. H. M. .

PEDIATRIC RHEUMATOLOGY, 2015, 13

[5] ASSOCIATIONS OF SOCIAL AND DEMOGRAPHIC-VARIABLES WITH CALCIUM INTAKES OF HIGH-SCHOOL-STUDENTS [J].

BARR, SI .

JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 1994, 94 (03) :260-266

[6] International longitudinal pediatric reference standards for bone mineral content [J].

Baxter-Jones, Adam D. G. ;

Burrows, Melonie ;

Bachrach, Laura K. ;

Lloyd, Tom ;

Petit, Moira ;

Macdonald, Heather ;

Mirwald, Robert L. ;

Bailey, Don ;

McKay, Heather .

BONE, 2010, 46 (01) :208-216

[7] Physical activity in children with Juvenile Idiopathic Arthritis compared to controls [J].

Bos, G. J. F. Joyce ;

Lelieveld, Otto T. H. M. ;

Armbrust, Wineke ;

Sauer, Pieter J. J. ;

Geertzen, Jan H. B. ;

Dijkstra, Pieter U. .

PEDIATRIC RHEUMATOLOGY, 2016, 14

[8] Childhood onset arthritis is associated with an increased risk of fracture: a population based study using the General Practice Research Database [J].

Burnham, J. M. ;

Shults, J. ;

Weinstein, R. ;

Lewis, J. D. ;

Leonard, M. B. .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (08) :1074-1079

[9] Bone density, structure, and strength in juvenile idiopathic arthritis [J].

Burnham, Jon M. ;

Shults, Justine ;

Dubner, Sarah E. ;

Sembhi, Harjeet ;

Zemel, Babette S. ;

Leonard, Mary B. .

ARTHRITIS AND RHEUMATISM, 2008, 58 (08) :2518-2527

[10] Bone disease in pediatric rheumatologic disorders. [J].

Burnham J.M. ;

Leonard M.B. .

Current Rheumatology Reports, 2004, 6 (1) :70-78

← 1 2 3 4 5 →