Precision medicine for psychopharmacology: a general introduction

被引：10

作者：

Shin, Cheolmin ^{[1
]}

Han, Changsu ^{[1
]}

Pae, Chi-Un ^{[2
]}

Patkar, Ashwin A. ^{[3
]}

机构：

[1] Korea Univ, Coll Med, Dept Psychiat, Seoul 136705, South Korea

[2] Catholic Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[3] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2016年 / 16卷 / 07期

关键词：

Precision medicine; personalized medicine; psychopharmacology; pharmacogenomics; pharmacometabolomics; exposomics; connectomics; big data; electronic health record; electronic medical record; DOMAIN CRITERIA RDOC; INDUCED WEIGHT-GAIN; ANTIDEPRESSANT RESPONSE; GENOMEWIDE ASSOCIATION; PERSONALIZED MEDICINE; PHARMACOGENETICS; VARIANTS; DYNAMICS; GENOMICS; PROJECT;

D O I：

10.1080/14737175.2016.1182022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Precision medicine is an emerging medical model that can provide accurate diagnoses and tailored therapeutic strategies for patients based on data pertaining to genes, microbiomes, environment, family history and lifestyle. Areas covered: Here, we provide basic information about precision medicine and newly introduced concepts, such as the precision medicine ecosystem and big data processing, and omics technologies including pharmacogenomics, pharamacometabolomics, pharmacoproteomics, pharmacoepigenomics, connectomics and exposomics. The authors review the current state of omics in psychiatry and the future direction of psychopharmacology as it moves towards precision medicine. Expert commentary: Advances in precision medicine have been facilitated by achievements in multiple fields, including large-scale biological databases, powerful methods for characterizing patients (such as genomics, proteomics, metabolomics, diverse cellular assays, and even social networks and mobile health technologies), and computer-based tools for analyzing large amounts of data.

引用

页码：831 / 839

页数：9

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