Integrin-mediated signalling of gelatinase B secretion in colon cancer cells

被引：85
作者：
Niu, J [1 ]
Gu, X
Turton, J
Meldrum, C
Howard, EW
Agrez, M
机构：
[1] Univ Newcastle, Fac Med & Hlth Sci, Discipline Surg Sci, Newcastle, NSW 2308, Australia
[2] John Hunter Hosp, Hunter Area Pathol Serv, New Lambton Hts, NSW 2305, Australia
[3] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 249卷 / 01期
关键词：
D O I：
10.1006/bbrc.1998.9128
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The progression of colon cancer has been linked to both cell adhesion molecules called integrins and matrix-degrading enzymes called metalloproteinases. Herein we report that the alpha v beta 6 integrin expressed in colon cancer cells induces gelatinase B secretion through the C-terminal cytoplasmic extension unique to the beta 6 integrin subunit, and that this ligand-independent event involves activation of the protein-kinase-C pathway. (C) 1998 Academic Press.
引用
收藏
页码：287 / 291
页数：5
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