Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions

被引：50

作者：

Cooke, G ^{[1
]}

de Cremiers, HA

Rotello, VM

Tarbit, B

Vanderstraeten, PE

机构：

[1] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland

[2] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[3] Seal Sands Chem Ltd, Middlesbrough TS2 1UB, Cleveland, England

来源：

TETRAHEDRON | 2001年 / 57卷 / 14期

基金：

英国工程与自然科学研究理事会; 美国国家科学基金会;

关键词：

triazines; Suzuki cross-coupling; tetrakis(triphenylphosphine)palladium; pyrimidines;

D O I：

10.1016/S0040-4020(01)00119-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The high yielding synthesis of 6-aryl-2,4-diaminopyrimidines and triazines via palladium catalysed Suzuki cross-coupling reactions of commercially available 6-chloro-2,4-diaminopyrimidine 1 or 6-chloro-2,4-diaminotriazine 8 and aryl boronic acids are described. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2787 / 2789

页数：3

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