Toxicity of jellyfish and sea-anemone venoms on cultured V79 cells

被引：25

作者：

Carli, A ^{[1
]}

Bussotti, S ^{[1
]}

Mariottini, GL ^{[1
]}

Robbiano, L ^{[1
]}

机构：

[1] UNIV GENOA,IST FARMACOL,I-16132 GENOA,ITALY

来源：

TOXICON | 1996年 / 34卷 / 04期

关键词：

D O I：

10.1016/0041-0101(95)00157-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cnidarian toxins exert an influence on human activities and public health. The cytotoxicity of crude toxins (nematocyst and surrounding tissue venom) of Aequorea aequorea, Rhizostoma pulmo and Anemonia sulcata was assessed on V79 cells. Rhizostoma pulmo and Anemonia sulcata crude venoms showed remarkable cytotoxicity and killed all treated cells at highest tested concentration within 2 and 3 hr, respectively. Aequorea aequorea crude venom greatly affected growth rate during long-term experiments. No genotoxic effect was observed. (C) 1996 Elsevier Science Ltd.

引用

页码：496 / 500

页数：5

共 24 条

[1]

ALLAVENA A, 1995, PHARM TOXICOL S1, V76, P31

[2]

Arillo A, 1994, Boll Soc Ital Biol Sper, V70, P307

[3] STRUCTURE ACTIVITY RELATIONSHIP (SAR) MODELS ESTABLISHED INVITRO WITH THE NEUTRAL RED CYTOTOXICITY ASSAY [J].