Acid-Catalyzed Pseudo Five-Component Annulation for a General One-Pot Synthesis of 2,4,6-Triaryl Pyrimidines

被引：18

作者：

Ding, Yuxin ^{[1
,2
]}

Ma, Renchao ^{[1
]}

Hider, Robert C. ^{[3
]}

Ma, Yongmin ^{[1
,2
]}

机构：

[1] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China

[2] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China

[3] Kings Coll London, Inst Pharmaceut Sci, Franklin Wilkins Bldg,Stamford St, London SE1 9NH, England

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 9卷 / 02期

关键词：

2; 4; 6-triaryl pyrimidines; annulation; pseudo five-component reaction; triflic acid; metal-free conditions; 2 DISCRETE NITRILES; SUBSTITUTED PYRIMIDINE; 2+2+2 CYCLOADDITIONS; COORDINATION ARRAYS; MECHANISTIC DETAILS; ANTITUMOR-ACTIVITY; COUPLING REACTIONS; IN-VITRO; DERIVATIVES; DESIGN;

D O I：

10.1002/ajoc.201900700

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and general synthesis of 2,4,6-triaryl pyrimidines has been developed. It involves a one-pot [2+1+1+1+1] pseudo five-component annulation of one methyl ketone, two aldehydes and two NH4OAc catalyzed by TfOH. One C-C and four C-N bonds are formed during the oxidative annulation process. The reaction shows good tolerance of many important functional groups in air and produces only water as the coproduct, making this methodology a highly versatile alternative to the existing methods for structuring pyrimidine framework.

引用

页码：242 / 246

页数：5

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