Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases

被引：18

作者：

Fukasawa, Takemichi ^{[1
]}

Yoshizaki-Ogawa, Asako ^{[1
]}

Enomoto, Atsushi ^{[2
]}

Miyagawa, Kiyoshi ^{[2
]}

Sato, Shinichi ^{[1
]}

Yoshizaki, Ayumi ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Dermatol, Tokyo 1138655, Japan

[2] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Lab Mol Radiol, Tokyo 1138655, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 15期

关键词：

palmoplantar pustulosis; B cells; T cells; IL-23; anti-IL-23; antibody; DOUBLE-BLIND; PSORIASIS; IL36RN; ACROSYRINGIUM; CYCLOSPORINE; EXPRESSION; OINTMENT; EFFICACY; MUTATION; SAFETY;

D O I：

10.3390/ijms23158261

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Palmoplantar pustulosis (PPP) is a disease that causes recurrent blisters and aseptic pustules on the palms and soles. It has been suggested that both innate and acquired immunity are involved. In particular, based on the tonsils and basic experiments, it has been assumed that T and B cells are involved in its pathogenesis. In addition, the results of clinical trials have suggested that IL-23 is closely related to the pathogenesis. This review describes PPP and the genetic background, the factors involved in the onset and exacerbation of disease and its relation to the molecular mechanism. In addition, we describe the usefulness of biological therapy and its implications in relation to the importance in pathology, the pathogenesis of PPP, the importance of the role of the IL-23-Th17 axis and IL-36 in PPP. Furthermore, we describe an animal experimental model of PPP, the efficacy and mechanism of action of guselkumab, an anti-IL-23 antibody, the latest research, and finally the possibility for it to be effective for other autoimmune diseases.

引用

页数：13

共 70 条

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