Precocious Puberty Associated with Testicular Hormone-secreting Leydig Cell Tumor

被引：3

作者：

Alagha, Eid ^{[1
]}

Kafi, Shahd E. ^{[1
]}

Shazly, Mohamed Abdelmaksoud ^{[1
]}

Al-Agha, Abdulmoein ^{[1
]}

机构：

[1] King Abdulaziz Univ Hosp, Pediat, Jeddah, Saudi Arabia

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2019年 / 11卷 / 12期

关键词：

leydig cell tumor; pseudo precocious puberty; testicular tumors; male children; PARATESTICULAR TUMORS; BOY;

D O I：

10.7759/cureus.6441

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leydig cell tumors (LCTs) are rare testicular tumors that may be a cause of precocious puberty in males. We present a 5-year-old boy with a five-month history of pubic hair appearance associated with an increase in penile length, scrotal hyperpigmentation, change in body odor, and bone age advanced by two years. His hormonal tests revealed the diagnosis of pseudo precocious puberty. Testicular ultrasound showed a unilateral right testicular enlargement. Surgery was performed to remove the mass. Histopathology confirmed the diagnosis of LCT. This case report highlights the importance of consideration of testicular tumors in boys with precocious puberty.

引用

页数：7

共 20 条

[1] Testicular and paratesticular tumours in the prepubertal population [J].

Ahmed, Hashim U. ;

Arya, Manit ;

Muneer, Asif ;

Mushtaq, Imran ;

Sebire, Neil .

LANCET ONCOLOGY, 2010, 11 (05) :476-483

[2] The Etiology and Clinical Features of Non-CAH Gonadotropin-Independent Precocious Puberty: A Multicenter Study [J].

Atay, Zeynep ;

Yesilkaya, Ediz ;

Erdeve, Senay Savas ;

Turan, Serap ;

Akin, Leyla ;

Eren, Erdal ;

Doger, Esra ;

Aycan, Zehra ;

Abali, Zehra Yavas ;

Akinci, Aysehan ;

Siklar, Zeynep ;

Ozen, Samim ;

Kara, Cengiz ;

Tayfun, Meltem ;

Sari, Erkan ;

Tutunculer, Filiz ;

Karabulut, Gulcan Seymen ;

Karaguzel, Gulay ;

Cetinkaya, Semra ;

Saglam, Halil ;

Bideci, Aysun ;

Kurtoglu, Selim ;

Guran, Tulay ;

Bereket, Abdullah .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (05) :1980-1988

[3] Long-term followup and clinical characteristics of testicular Leydig cell tumor: Experience with 24 cases [J].

Carmignani, Luca ;

Salvioni, Roberto ;

Gadda, Franco ;

Colecchia, Maurizio ;

Gazzano, Giacomo ;

Torelli, Tullio ;

Rocco, Francesco ;

Colpi, Giovanni Maria ;

Pizzocaro, Giorgio .

JOURNAL OF UROLOGY, 2006, 176 (05) :2040-2043

[4]

Castillo Orihuela SY, 2017, ENDOCRINOL METAB INT, V5, P168, DOI [10.15406/emij.2017.05.00109, DOI 10.15406/EMIJ.2017.05.00109]

[5] PRIMARY TESTICULAR AND PARATESTICULAR TUMORS OF CHILDHOOD [J].

COPPES, MJ ;

RACKLEY, R ;

KAY, R .

MEDICAL AND PEDIATRIC ONCOLOGY, 1994, 22 (05) :329-340

[6]

CRISCUOLO T, 1986, ANDROLOGIA, V18, P175

[7] Peripheral Precocious Puberty: Causes and Current Management [J].

Eugster, Erica A. .

HORMONE RESEARCH, 2009, 71 :64-67

[8]

Ghazi AAM, 2001, J PEDIATR ENDOCR MET, V14, P1679

[9] A BOY WITH LEYDIG-CELL TUMOR AND PRECOCIOUS PUBERTY - ULTRASONOGRAPHY AS A DIAGNOSTIC-AID [J].

ILONDO, MM ;

VANDENMOOTER, F ;

MARCHAL, G ;

VEREECKEN, R ;

WYNANTS, P ;

LAUWERYNS, JM ;

EECKELS, R ;

VANDERSCHUERENLODEWEYCKX, M .

EUROPEAN JOURNAL OF PEDIATRICS, 1981, 137 (02) :221-227

[10] Clinical and metabolic findings in a 6-year-old boy with a Leydig cell tumour [J].

Lignitz, S. ;

Partsch, C. J. ;

Wudy, S. A. ;

Hartmann, M. F. ;

Pohlenz, J. .

ACTA PAEDIATRICA, 2011, 100 (12) :E280-E282

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