Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer's disease

被引：187

作者：

Vural, Huseyin ^{[1
]}

Demirin, Hilmi ^{[1
]}

Kara, Yusuf ^{[1
]}

Eren, Ibrahim ^{[2
]}

Delibas, Namik ^{[1
]}

机构：

[1] Suleyman Demirel Univ, Dept Biochem, Fac Med, TR-32260 Isparta, Turkey

[2] Suleyman Demirel Univ, Dept Psychiat, Fac Med, TR-32260 Isparta, Turkey

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2010年 / 24卷 / 03期

关键词：

Alzheimer's disease; Trace elements; Antioxidant enzymes; SUPEROXIDE-DISMUTASE; GLUTATHIONE-PEROXIDASE; CEREBROSPINAL-FLUID; OXIDATIVE STRESS; SERUM ZINC; BRAIN; DEFICIENCY; MALONDIALDEHYDE; DETERIORATION; INVOLVEMENT;

D O I：

10.1016/j.jtemb.2010.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present study is to evaluate the status of plasma essential trace elements magnesium (Mg), copper (Cu), zinc (Zn), iron (Fe) and selenium (Se) concentrations and their some related antioxidant enzyme activities, erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities in patients with Alzheimer's disease (AD). Fifty patients with AD and fifty healthy control subjects were included in this study. Plasma Cu and Zn concentrations by atomic absorption spectrometry (AAS), plasma Mg and Fe concentrations by spectrophotometric methods and plasma Se concentrations by graphite furnace AAS were determined. Erythrocyte GPx, SOD and CAT activities were measured by spectrophotometric methods. Plasma Mg, Cu, Zn, Fe and Se levels and erythrocyte GPx. SOD and CAT activities were found to be significantly lower in patients with AD compared with controls. These results suggest that alterations in essential trace elements and their related enzymes may play a role in the etiopathogenesis of AD. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with AD. The changes in antioxidant enzyme activities may be secondary to the alterations in their cofactor concentrations. (C) 2010 Elsevier GmbH. All rights reserved.

引用

页码：169 / 173

页数：5

共 43 条

[1]

AEBI H, 1984, METHOD ENZYMOL, V105, P121

[2]

Andrási E, 2000, MAGNESIUM RES, V13, P189

[3] INCREASED GLUTATHIONE-PEROXIDASE ACTIVITY IN ERYTHROCYTES IN PATIENTS WITH ALZHEIMERS-DISEASE SENILE DEMENTIA OF ALZHEIMERS TYPE [J].

ANNEREN, G ;

GARDNER, A ;

LUNDIN, T .

ACTA NEUROLOGICA SCANDINAVICA, 1986, 73 (06) :586-589

[4]

BASUN H, 1991, J NEURAL TRANSM-PARK, V3, P231

[5] Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice [J].

Bayer, TA ;

Schäfer, S ;

Simons, A ;

Kemmling, A ;

Kamer, T ;

Tepest, R ;

Eckert, A ;

Schüssel, K ;

Eikenberg, O ;

Sturchler-Pierrat, C ;

Abramowski, D ;

Staufenbiel, M ;

Multhaup, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) :14187-14192

[6]

BEARD JL, 1993, NUTR REV, V51, P157, DOI 10.1111/j.1753-4887.1993.tb03096.x

[7] EVIDENCE FOR SPECIFIC SELENIUM TARGET TISSUES AND NEW BIOLOGICALLY IMPORTANT SELENOPROTEINS [J].

BEHNE, D ;

HILMERT, H ;

SCHEID, S ;

GESSNER, H ;

ELGER, W .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 966 (01) :12-21

[8] Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities [J].

Bressler, Joseph P. ;

Olivi, Luisa ;

Cheong, Jae Hoon ;

Kim, Yongbae ;

Maerten, Alex ;

Bannon, Desmond .

HUMAN & EXPERIMENTAL TOXICOLOGY, 2007, 26 (03) :221-229

[9]

Campbell A, 2006, J ALZHEIMERS DIS, V10, P165

[10] Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias [J].

Casado, Angela ;

Lopez-Fernandez, Ma Encarnacion ;

Casado, Ma Concepcion ;

de la Torre, Rosario .

NEUROCHEMICAL RESEARCH, 2008, 33 (03) :450-458

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