The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

被引：47

作者：

Archibald, Stephen J. ^{[1
,2
,3
]}

Allott, Louis ^{[1
,2
,3
]}

机构：

[1] Univ Hull, Fac Hlth Sci, Positron Emiss Tomog Res Ctr, Cottingham Rd, Kingston Upon Hull HU6 7RX, Yorks, England

[2] Univ Hull, Fac Hlth Sci, Dept Biomed Sci, Cottingham Rd, Kingston Upon Hull HU6 7RX, Yorks, England

[3] Hull Univ Teaching Hosp NHS Trust, Castle Hill Hosp, Castle Rd, Cottingham HU16 5JQ, England

来源：

EJNMMI RADIOPHARMACY AND CHEMISTRY | 2021年 / 6卷 / 01期

基金：

英国医学研究理事会;

关键词：

Aluminium-[F-18]fluoride; F-18]AlF; Radiometal; Chelation; Radioconjugate; IMAGING INTEGRIN ALPHA-V-BETA-3; PROSTATE-CANCER; AFFIBODY MOLECULE; RADIATION-DOSIMETRY; CXCR4; EXPRESSION; PEPTIDE RECEPTOR; LUNG-CANCER; CONCURRENT CHEMORADIOTHERAPY; SENSITIVE BIOMOLECULES; F-18-ALFATIDE II;

D O I：

10.1186/s41181-021-00141-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aluminium-[F-18]fluoride ([F-18]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [F-18]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [F-18]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.

引用

页数：28

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