Ruthenium(II) complexes of 1,12-diazaperyiene and their interactions with DNA

被引：126

作者：

Chouai, A

Wicke, SE

Turro, C ^{[1
]}

Bacsa, J

Dunbar, KR

Wang, D

Thummel, RP

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

[2] Univ Houston, Dept Chem, Houston, TX 77204 USA

[3] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

INORGANIC CHEMISTRY | 2005年 / 44卷 / 17期

关键词：

D O I：

10.1021/ic0485965

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Four complexes of the ligand 1,12-diazaperylene (DAP) have been prepared, [Ru(bpy)(n)(DAP)(3-n)](2+) where n = 0-2 and [Ru(DAP)(3)](2+). The [Ru(DAP)(3)](2+) complex was characterized by X-ray analysis and was found to exhibit the expected propeller-like structure with significant intermolecular pi-stacking interactions. The three Ru(II) complexes showed self-consistent optoelectronic properties with similar ligand-centered pi-pi(*) absorptions in the range of 333-468 nm and MLCT bands associated with the DAP which increased in intensity and decreased in energy as the number of DAP ligands varied from 1 to 3. Hypochromicity and viscosity changes were observed that were consistent with DAP intercalation into DNA, and binding constants were measured in the range of 1.4-1.6 x 10(6) M-1 for the mixed ligand complexes. Furthermore, the complex [Ru(bpy)(2)(DAP)](2+) was found to photocleave plasmid DNA upon irradiation with visible light.

引用

页码：5996 / 6003

页数：8

共 46 条

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