Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era

被引：2
|
作者：
Watson, James A. [1 ,2 ]
White, Nicholas J. [1 ,2 ]
Dondorp, Arjen M. [1 ,2 ]
机构：
[1] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand
[2] Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England
来源：
TRENDS IN PARASITOLOGY | 2022年 / 38卷 / 01期
基金：
英国惠康基金;
关键词：
SICKLE; TRAIT;
D O I：
10.1016/j.pt.2021.10.005
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.
引用
收藏
页码：11 / 14
页数：4
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