The Diagnostic, Prognostic and Therapeutic Role of miRNAs in Adrenocortical Carcinoma: A Systematic Review

被引：5

作者：

Mytareli, Chrysoula ^{[1
]}

Delivanis, Danae A. ^{[2
]}

Athanassouli, Fani ^{[1
]}

Kalotychou, Vassiliki ^{[1
]}

Mantzourani, Marina ^{[1
]}

Kassi, Eva ^{[3
,4
]}

Angelousi, Anna ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Sch Med, Dept Internal Med, Athens 11527, Greece

[2] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA

[3] Natl & Kapodistrian Univ Athens, Sch Med, Dept Biol Chem, Athens 11527, Greece

[4] Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Propaedeut & Internal Med, Athens 11527, Greece

来源：

BIOMEDICINES | 2021年 / 9卷 / 11期

关键词：

microRNAs; adrenocortical carcinoma; biomarkers; diagnosis; prognosis; therapy; GENOMIC CHARACTERIZATION; MICRORNA; EXPRESSION; INVASION; TUMORS; PROLIFERATION; PATHOGENESIS; SUPPRESSES; MIR-483-5P; SIGNATURE;

D O I：

10.3390/biomedicines9111501

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a dismal prognosis and a high rate of recurrence and mortality. Therapeutic options are limited. In some cases, the distinction of ACCs from benign adrenal neoplasms with the existing widely available pathological and histopathological tools is difficult. Thus, new biomarkers have been tested. We conducted a review of the recent literature on the advances of the diagnostic, prognostic and therapeutic role of miRNAs on ACC patients. More than 10 miRNAs validated by multiple studies were found to present a diagnostic and prognostic role for ACC patients, from which miR-483-5p and miR-195 were the most frequently met biomarkers. In particular, upregulation of miR-483-5p and downregulation of miR-195 were the most commonly validated molecular alterations. Unfortunately, data on the therapeutic role of miRNA are still scarce and limited mainly at the experimental level. Thus, the role of miRNA regulation in ACC remains an area of active research.

引用

页数：21

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