Nanotechnology-Based Drug Delivery Systems for Melanoma Antitumoral Therapy: A Review

被引：62
|
作者：
Rigon, Roberta Balansin [1 ]
Oyafuso, Marcia Helena [1 ]
Fujimura, Andressa Terumi [1 ]
Goncalez, Maria Lima [1 ]
do Prado, Alice Haddad [1 ]
Daflon Gremiao, Maria Palmira [1 ]
Chorilli, Marlus [1 ]
机构：
[1] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Drug & Med, BR-14801902 Araraquara, SP, Brazil
来源：
BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷
基金：
巴西圣保罗研究基金会;
关键词：
SOLID LIPID NANOPARTICLES; LOW-DENSITY-LIPOPROTEIN; METASTATIC MALIGNANT-MELANOMA; POSITRON-EMISSION-TOMOGRAPHY; LIQUID-CRYSTALLINE SYSTEMS; IRON-OXIDE NANOPARTICLES; T4; ENDONUCLEASE-V; IN-VITRO; BETA-CYCLODEXTRIN; POLYMERIC NANOPARTICLES;
D O I：
10.1155/2015/841817
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Melanoma (MEL) is a less common type of skin cancer, but it is more aggressive with a high mortality rate. The World Cancer Research Fund International (GLOBOCAN 2012) estimates that there were 230,000 new cases of MEL in the world in 2012. Conventional MEL treatment includes surgery and chemotherapy, but many of the chemotherapeutic agents used present undesirable properties. Drug delivery systems are an alternative strategy by which to carry antineoplastic agents. Encapsulated drugs are advantageous due to such properties as high stability, better bioavailability, controlled drug release, a long blood circulation time, selective organ or tissue distribution, a lower total required dose, and minimal toxic side effects. This review of scientific research supports applying a nanotechnology-based drug delivery system for MEL therapy.
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页数：22
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