Charting a course through the CEAs: diagnosis and management of medullary thyroid cancer

被引:1
作者
Rowe, Christopher W. [1 ,2 ]
Bendinelli, Cino [2 ,3 ]
McGrath, Shaun [1 ]
机构
[1] John Hunter Hosp, Dept Endocrinol, Newcastle, NSW, Australia
[2] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia
[3] John Hunter Hosp, Dept Surg, Newcastle, NSW, Australia
关键词
SERUM CALCITONIN; PROGNOSTIC-FACTORS; CARCINOMA; F-18-DOPA; F-18-FDG; FEATURES; PET/CT; IMPACT;
D O I
10.1111/cen.13114
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Medullary thyroid cancer (MTC) is an uncommon thyroid cancer that requires a high index of suspicion to facilitate diagnosis of early-stage disease amenable to surgical cure. The challenges of diagnosis, as well as management in the setting of persistent disease, are explored in the context of a case presenting with the incidental finding of elevated carcinoembryonic antigen (CEA) and an F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET)-positive thyroid incidentaloma detected following treatment of colorectal cancer. Strategies to individualize prognosis, and emerging PET-based imaging modalities, particularly the potential role of F-18-DOPA-PET in staging, are reviewed.
引用
收藏
页码:340 / 343
页数:4
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共 25 条
  • [1] Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma
    Barbet, J
    Campion, L
    Kraeber-Bodéré, F
    Chatal, JF
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (11) : 6077 - 6084
  • [2] Medullary thyroid carcinoma:: Pitfalls in diagnosis by fine needle aspiration cytology and relationship of cytomorphology to RET proto-oncogene mutations
    Chang, TC
    Wu, SL
    Hsiao, YL
    [J]. ACTA CYTOLOGICA, 2005, 49 (05) : 477 - 482
  • [3] Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules
    Costante, Giuseppe
    Meringolo, Domenico
    Durante, Cosimo
    Bianchi, Davide
    Nocera, Maria
    Tumino, Salvatore
    Crocetti, Umberto
    Attard, Marco
    Maranghi, Marianna
    Torlontano, Massimo
    Filetti, Sebastiano
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (02) : 450 - 455
  • [4] Early Diagnosis of Medullary Thyroid Carcinoma: Is Systematic Calcitonin Screening Appropriate in Patients with Nodular Thyroid Disease?
    Costante, Giuseppe
    Filetti, Sebastiano
    [J]. ONCOLOGIST, 2011, 16 (01) : 49 - 52
  • [5] Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: Experience in 10,864 patients with nodular thyroid disorders
    Elisei, R
    Bottici, V
    Luchetti, F
    Di Coscio, G
    Romei, C
    Grasso, L
    Miccoli, P
    Iacconi, P
    Basolo, F
    Pinchera, A
    Pacini, F
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (01) : 163 - 168
  • [6] Cabozantinib in Progressive Medullary Thyroid Cancer
    Elisei, Rossella
    Schlumberger, Martin J.
    Mueller, Stefan P.
    Schoffski, Patrick
    Brose, Marcia S.
    Shah, Manisha H.
    Licitra, Lisa
    Jarzab, Barbara
    Medvedev, Viktor
    Kreissl, Michael C.
    Niederle, Bruno
    Cohen, Ezra E. W.
    Wirth, Lori J.
    Ali, Haythem
    Hessel, Colin
    Yaron, Yifah
    Ball, Douglas
    Nelkin, Barry
    Sherman, Steven I.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (29) : 3639 - +
  • [7] Medullary Thyroid Cancer: It is a pain in the neck?
    Guerrero, Marlon A.
    Lindsay, Sheila
    Suh, Insoo
    Vriens, Menno R.
    Khanafshar, Elham
    Shen, Wen T.
    Gosnell, Jessica
    Kebebew, Electron
    Duh, Quan-Yang
    Clark, Orlo H.
    [J]. JOURNAL OF CANCER, 2011, 2 : 200 - 205
  • [8] How to Incorporate New Tyrosine Kinase Inhibitors in the Treatment of Patients With Medullary Thyroid Cancer
    Haddad, Robert I.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (29) : 3618 - 3620
  • [9] MEDULLARY (SOLID) CARCINOMA OF THE THYROID - CLINICOPATHOLOGIC ENTITY
    HAZARD, JB
    HAWK, WA
    CRILE, G
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1959, 19 (01) : 152 - 161
  • [10] Diagnosis of medullary thyroid carcinoma by calcitonin measurement in fine-needle aspiration biopsy specimens
    Kudo, Takumi
    Miyauchi, Akira
    Ito, Yasuhiro
    Takamura, Yuuki
    Amino, Nobuyuki
    Hirokawa, Mitsuhiro
    [J]. THYROID, 2007, 17 (07) : 635 - 638