Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma: Role of the Radiologist and Oncologist in the Era of Precision Medicine

被引：13

作者：

Vernuccio, Federica ^{[1
]}

Messina, Carlo ^{[2
]}

Merz, Valeria ^{[3
]}

Cannella, Roberto ^{[4
,5
]}

Midiri, Massimo ^{[4
]}

机构：

[1] Univ Hosp Paolo Giaccone, Radiol Unit, I-90127 Palermo, Italy

[2] ARNAS Civ, Oncol Unit, I-90127 Palermo, Italy

[3] Santa Chiara Hosp, Dept Med Oncol, I-38122 Trento, Italy

[4] Univ Hosp Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, Via Vespro 129, I-90127 Palermo, Italy

[5] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties PROMISE, Via Vespro 129, I-90127 Palermo, Italy

来源：

DIAGNOSTICS | 2021年 / 11卷 / 11期

关键词：

pancreatic ductal adenocarcinoma; pancreatic neoplasm; computed tomography (CT); magnetic resonance imaging (MRI); SPECTRAL MULTIDETECTOR CT; CANCER AMERICAN SOCIETY; NEOADJUVANT THERAPY; INTERNATIONAL CONSENSUS; INDUCTION CHEMOTHERAPY; CHEMORADIATION THERAPY; ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; TEXTURE ANALYSIS; PERFUSION-CT;

D O I：

10.3390/diagnostics11112166

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The incidence and mortality of pancreatic ductal adenocarcinoma are growing over time. The management of patients with pancreatic ductal adenocarcinoma involves a multidisciplinary team, ideally involving experts from surgery, diagnostic imaging, interventional endoscopy, medical oncology, radiation oncology, pathology, geriatric medicine, and palliative care. An adequate staging of pancreatic ductal adenocarcinoma and re-assessment of the tumor after neoadjuvant therapy allows the multidisciplinary team to choose the most appropriate treatment for the patient. This review article discusses advancement in the molecular basis of pancreatic ductal adenocarcinoma, diagnostic tools available for staging and tumor response assessment, and management of resectable or borderline resectable pancreatic cancer.

引用

页数：16

共 117 条

[1] Randomized multicenter phase II/III study with adjuvant gemcitabine versus neoadjuvant/adjuvant FOLFIRINOX in resectable pancreatic cancer: The NEPAFOX trial. [J].

Al-Batran, Salah-Eddin ;

Reichart, Alexander ;

Bankstahl, Ulli Simone ;

Pauligk, Claudia ;

Kraus, Thomas Werner ;

Bechstein, Wolf Otto ;

Trojan, Jorg ;

Behrend, Matthias ;

Potenberg, Jochem ;

Homann, Nils ;

Venerito, Marino ;

Bohle, Wolfram ;

Varvenne, Michael ;

Bolling, Claus ;

Behringer, Dirk M. ;

Kratz-Alber, Karsten ;

Siegler, Gabriele Margareta ;

Hozaeel, Wael ;

Goetze, Thorsten Oliver .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)

[2] Pancreatic Ductal Adenocarcinoma Radiology Reporting Template: Consensus Statement of the Society of Abdominal Radiology and the American Pancreatic Association [J].

Al-Hawary, Mahmoud M. ;

Francis, Isaac R. ;

Chari, Suresh T. ;

Fishman, Elliot K. ;

Hough, David M. ;

Lu, David S. ;

Macari, Michael ;

Megibow, Alec J. ;

Miller, Frank H. ;

Mortele, Koenraad J. ;

Merchant, Nipun B. ;

Minter, Rebecca M. ;

Tamm, Eric P. ;

Sahani, Dushyant V. ;

Simeone, Diane M. .

RADIOLOGY, 2014, 270 (01) :248-260

[3] Neoadjuvant Chemotherapy Switch in Borderline Resectable/Locally Advanced Pancreatic Cancer [J].

Alva-Ruiz, Roberto ;

Yohanathan, Lavanya ;

Yonkus, Jennifer A. ;

Abdelrahman, Amro M. ;

Gregory, Lindsey A. ;

Halfdanarson, Thorvadur R. ;

Mahipal, Amit ;

McWilliams, Robert R. ;

Ma, Wen Wee ;

Hallemeier, Christopher L. ;

Graham, Rondell P. ;

Grotz, Travis E. ;

Smoot, Rory L. ;

Cleary, Sean P. ;

Nagorney, David M. ;

Kendrick, Michael L. ;

Truty, Mark J. .

ANNALS OF SURGICAL ONCOLOGY, 2022, 29 (03) :1579-1591

[4]

[Anonymous], Cancer Stat Facts: Pancreatic Cancer

[5] Genomic analyses identify molecular subtypes of pancreatic cancer [J].

Bailey, Peter ;

Chang, David K. ;

Nones, Katia ;

Johns, Amber L. ;

Patch, Ann-Marie ;

Gingras, Marie-Claude ;

Miller, David K. ;

Christ, Angelika N. ;

Bruxner, Tim J. C. ;

Quinn, Michael C. ;

Nourse, Craig ;

Murtaugh, L. Charles ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Manning, Suzanne ;

Nourbakhsh, Ehsan ;

Wani, Shivangi ;

Fink, Lynn ;

Holmes, Oliver ;

Chin, Vencssa ;

Anderson, Matthew J. ;

Kazakoff, Stephen ;

Leonard, Conrad ;

Newell, Felicity ;

Waddell, Nick ;

Wood, Scott ;

Xu, Qinying ;

Wilson, Peter J. ;

Cloonan, Nicole ;

Kassahn, Karin S. ;

Taylor, Darrin ;

Quek, Kelly ;

Robertson, Alan ;

Pantano, Lorena ;

Mincarelli, Laura ;

Sanchez, Luis N. ;

Evers, Lisa ;

Wu, Jianmin ;

Pinese, Mark ;

Cowley, Mark J. ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chantrill, Lorraine A. ;

Mawson, Amanda ;

Humphris, Jeremy ;

Chou, Angela ;

Pajic, Marina ;

Scarlett, Christopher J. .

NATURE, 2016, 531 (7592) :47-+

[6] Preoperative Imaging Evaluation after Downstaging of Pancreatic Ductal Adenocarcinoma: A Multi-Center Study [J].

Beleu, Alessandro ;

Calabrese, Angela ;

Rizzo, Giulio ;

Capelli, Paola ;

Bellini, Nicolo ;

Caloggero, Simona ;

Calbi, Roberto ;

Martini, Paolo Tinazzi ;

De Robertis, Riccardo ;

Carbognin, Giovanni ;

Marchegiani, Giovanni ;

Scarpa, Aldo ;

Salvia, Roberto ;

Bassi, Claudio ;

D'Onofrio, Mirko .

CANCERS, 2019, 11 (02)

[7] Characterizing indeterminate liver lesions in patients with localized pancreatic cancer at the time of diagnosis [J].

Bhalla, Manav ;

Aldakkak, Mohammed ;

Kulkarni, Naveen M. ;

O'Connor, Stacy D. ;

Griffin, Michael O., Jr. ;

Christians, Kathleen K. ;

Evans, Douglas B. ;

Tsai, Susan ;

Tolat, Parag P. .

ABDOMINAL RADIOLOGY, 2018, 43 (02) :351-363

[8] Borderline resectable pancreatic cancer: A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS) [J].

Bockhorn, Maximilian ;

Uzunoglu, Faik G. ;

Adham, Mustapha ;

Imrie, Clem ;

Milicevic, Miroslav ;

Sandberg, Aken A. ;

Asbun, Horacio J. ;

Bassi, Claudio ;

Buechler, Markus ;

Charnley, Richard M. ;

Conlon, Kevin ;

Cruz, Laureano Fernandez ;

Dervenis, Christos ;

Fingerhutt, Abe ;

Friess, Helmut ;

Gouma, Dirk J. ;

Hartwig, Werner ;

Lillemoe, Keith D. ;

Montorsi, Marco ;

Neoptolemos, John P. ;

Shrikhande, Shailesh V. ;

Takaori, Kyoichi ;

Traverso, William ;

Vashist, Yogesh K. ;

Vollmer, Charles ;

Yeo, Charles J. ;

Izbicki, Jakob R. .

SURGERY, 2014, 155 (06) :977-988

[9] Assessment of Response to Neoadjuvant Therapy Using CT Texture Analysis in Patients With Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma [J].

Borhani, Amir A. ;

Dewan, Rohit ;

Furlan, Alessandro ;

Seiser, Natalie ;

Zureikat, Amer H. ;

Singhi, Aatur D. ;

Boone, Brian ;

Bahary, Nathan ;

Hogg, Melissa E. ;

Lotze, Michael ;

Zeh, Herbert J., III ;

Tublin, Mitchell E. .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2020, 214 (02) :362-369

[10] Detection of small pancreatic tumors with multiphasic helical CT [J].

Bronstein, YL ;

Loyer, EM ;

Kaur, H ;

Choi, H ;

David, C ;

DuBrow, RA ;

Broemeling, LD ;

Cleary, KR ;

Charnsangavej, C .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2004, 182 (03) :619-623

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