Correlation between the growth of uterine leiomyomata and estrogen and progesterone receptor content in needle biopsy specimens

被引：56
作者：
Ichimura, T [1 ]
Kawamura, N [1 ]
Ito, F [1 ]
Shibata, S [1 ]
Minakuchi, K [1 ]
Tsujimura, A [1 ]
Umesaki, N [1 ]
Ogita, S [1 ]
机构：
[1] Osaka City Univ, Sch Med, Dept Obstet & Gynecol, Abeno Ku, Osaka 5458585, Japan
来源：
FERTILITY AND STERILITY | 1998年 / 70卷 / 05期
基金：
美国国家卫生研究院;
关键词：
uterine leiomyoma; natural history; estrogen receptor; progesterone receptor; needle biopsy;
D O I：
10.1016/S0015-0282(98)00300-8
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To examine the relationship between estrogen receptor (ER) and progesterone receptor (PR) content in needle biopsy specimens and the growth of uterine leiomyomata after biopsy. Design: Prospective clinical study. Setting: University teaching hospital. Patient(s): Thirty-one women with uterine leiomyomata and a normal menstrual cycle. Intervention(s): Transcervical needle biopsy of uterine leiomyomata. Main Outcome Measure(s): The relationships between histologic features (smooth muscle content, immunohistochemical expression of ER and PR) and the percent increase over a 12-month observation period in the volume of the largest myoma nodule measured by magnetic resonance imaging were analyzed. Result(s): Both the density and intensity of immunohistochemical staining of PRs in uterine leiomyoma tissue showed significant positive correlation with leiomyoma growth. Conclusion(s): The growth of uterine leiomyomata can be determined by histologic and immunohistochemical analysis of needle biopsy specimens from uterine leiomyomata. (Fertil Steril(R) 1998;70:967-71. (C) 1998 by American Society for Reproductive Medicine.).
引用
收藏
页码：967 / 971
页数：5
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