Common Genomic Aberrations in Basaloid Squamous Cell Carcinoma and Carcinosarcoma of the Esophagus Detected by CGH and Array CGH

被引：13

作者：

Schaefer, Inga-Marie ^{[1
]}

Enders, Christina ^{[1
]}

Polten, Andreas ^{[4
]}

Haller, Florian ^{[1
]}

Froelich, Andreas M. J. ^{[1
]}

Cameron, Silke ^{[2
]}

Schueler, Philipp ^{[3
]}

Schweiger, Peter ^{[5
]}

Gunawan, Bastian ^{[1
]}

Beham, Alexander ^{[3
]}

Fuezesi, Laszlo ^{[1
]}

机构：

[1] Univ Med Ctr Gottingen, Dept Gastroenteropathol, D-37075 Gottingen, Germany

[2] Univ Med Ctr Gottingen, Dept Gastroenterol & Endocrinol, D-37075 Gottingen, Germany

[3] Univ Med Ctr Gottingen, Dept Gen & Visceral Surg, D-37075 Gottingen, Germany

[4] Agilent Technol, Waldbronn, Germany

[5] Protestant Hosp Weende, Dept Internal Med, Gottingen, Germany

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2011年 / 135卷 / 04期

关键词：

Basaloid squamous cell carcinoma; Carcinosarcoma; Esophagus; Array comparative genomic hybridization; CANCER; GENE;

D O I：

10.1309/AJCPZ1O7UUUISPNR

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies. Comparative genomic hybridization (CGH) in 1 case of BSCC and 2 cases of carcinosarcoma and subsequent array CGH in 1 case each of BSCC and carcinosarcoma revealed common chromosomal gains at 2p25.3-2p12, 7q21.3-7q22.3, and 11q13.2-11q13.4. Chromosomal losses at 13q31qter were observed in both carcinosarcomas. In addition, progression of genomic instability from in situ to invasive carcinosarcoma could be demonstrated by using array CGH. Our observations suggest a common genetic origin of BSCC and carcinosarcoma.

引用

页码：579 / 586

页数：8

共 44 条

[41] Rapid-growth carcinosarcoma of the esophagus arising from 0-IIc squamous cell carcinoma after definitive chemoradiotherapy: a case report
Nakagawa, Satoru
Yabusaki, Hiroshi
Tanaka, Otsuo
ESOPHAGUS, 2009, 6 (02) : 123 - 126
[42] Rapid-growth carcinosarcoma of the esophagus arising from 0-IIc squamous cell carcinoma after definitive chemoradiotherapy: a case report
Satoru Nakagawa
Hiroshi Yabusaki
Otsuo Tanaka
Esophagus, 2009, 6 : 123 - 126
[43] A variant Cri du Chat phenotype and autism spectrum disorder in a subject with de novo cryptic microdeletions involving 5p15.2 and 3p24.3-25 detected using whole genomic array CGH
Harvard, C
Malenfant, P
Koochek, M
Creighton, S
Mickelson, ECR
Holden, JJA
Lewis, MES
Rajcan-Separovic, E
CLINICAL GENETICS, 2005, 67 (04) : 341 - 351
[44] High frequency of common DNA copy number abnormalities detected by bacterial artificial chromosome array comparative genomic hybridization in 24 breast cancer cell lines
Saito, Soichiro
Morita, Keiko
Hirano, Takashi
HUMAN CELL, 2009, 22 (01): : 1 - 10

← 1 2 3 4 5 →