Common Genomic Aberrations in Basaloid Squamous Cell Carcinoma and Carcinosarcoma of the Esophagus Detected by CGH and Array CGH

被引：13
|
作者：
Schaefer, Inga-Marie [1 ]
Enders, Christina [1 ]
Polten, Andreas [4 ]
Haller, Florian [1 ]
Froelich, Andreas M. J. [1 ]
Cameron, Silke [2 ]
Schueler, Philipp [3 ]
Schweiger, Peter [5 ]
Gunawan, Bastian [1 ]
Beham, Alexander [3 ]
Fuezesi, Laszlo [1 ]
机构：
[1] Univ Med Ctr Gottingen, Dept Gastroenteropathol, D-37075 Gottingen, Germany
[2] Univ Med Ctr Gottingen, Dept Gastroenterol & Endocrinol, D-37075 Gottingen, Germany
[3] Univ Med Ctr Gottingen, Dept Gen & Visceral Surg, D-37075 Gottingen, Germany
[4] Agilent Technol, Waldbronn, Germany
[5] Protestant Hosp Weende, Dept Internal Med, Gottingen, Germany
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2011年 / 135卷 / 04期
关键词：
Basaloid squamous cell carcinoma; Carcinosarcoma; Esophagus; Array comparative genomic hybridization; CANCER; GENE;
D O I：
10.1309/AJCPZ1O7UUUISPNR
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies. Comparative genomic hybridization (CGH) in 1 case of BSCC and 2 cases of carcinosarcoma and subsequent array CGH in 1 case each of BSCC and carcinosarcoma revealed common chromosomal gains at 2p25.3-2p12, 7q21.3-7q22.3, and 11q13.2-11q13.4. Chromosomal losses at 13q31qter were observed in both carcinosarcomas. In addition, progression of genomic instability from in situ to invasive carcinosarcoma could be demonstrated by using array CGH. Our observations suggest a common genetic origin of BSCC and carcinosarcoma.
引用
收藏
页码：579 / 586
页数：8
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