Glucagon-like peptide 2: A key link between nutrition and intestinal adaptation in neonates?

被引:37
作者
Burrin, D [1 ]
Guan, XF
Stoll, B
Petersen, YM
Sangild, PT
机构
[1] Baylor Coll Med, USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Houston, TX 77030 USA
[2] Royal Vet & Agr Univ, Div Anim Nutr, DK-1870 Copenhagen, Denmark
关键词
cell proliferation; apoptosis; gut hormone; enteral nutrition; blood flow; nitric oxide;
D O I
10.1093/jn/133.11.3712
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
This paper reviews the evidence from recent studies in young piglets to examine the hypothesis that glucagon-like peptide 2 (GLP-2) is a physiologically relevant hormonal signal linked to the intestinal adaptation associated with enteral nutrition in neonates. Observations that support the hypothesis include, 1) the GLP-2 secretory response to enteral nutrition is functional as early as late gestation, 2) parallel changes in intestinal growth and circulating GLP-2 occur in response to the quantity and composition of enteral nutrition after birth, and 3) the acute temporal changes in intestinal metabolism and circulating GLP-2 concentrations in response to enteral nutrition are generally coincident. In contrast, however, the lack of intestinal trophic responses to both pharmacological GLP-2 concentrations in the fetus and weanling pigs, and to physiological GLP-2 concentrations in neonates raises doubts concerning the physiological relevance of GLP-2 as a enterally mediated trophic signal. A more definitive test of this hypothesis will require further studies that assess the intestinal metabolic response to enteral nutrition using experimental approaches that block GLP-2 action.
引用
收藏
页码:3712 / 3716
页数:5
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