The gut microbiome in atherosclerotic cardiovascular disease

被引：1121

作者：

Jie, Zhuye ^{[1
,2
,3
]}

Xia, Huihua ^{[1
,2
]}

Zhong, Shi-Long ^{[4
,5
]}

Feng, Qiang ^{[1
,2
,6
,7
,18
]}

Li, Shenghui ^{[1
]}

Liang, Suisha ^{[1
,2
]}

Zhong, Huanzi ^{[1
,2
,3
,7
]}

Liu, Zhipeng ^{[1
,8
]}

Gao, Yuan ^{[1
,2
]}

Zhao, Hui ^{[1
]}

Zhang, Dongya ^{[1
]}

Su, Zheng ^{[1
]}

Fang, Zhiwei ^{[1
]}

Lan, Zhou ^{[1
]}

Li, Junhua ^{[1
,2
,3
,9
]}

Xiao, Liang ^{[1
,2
]}

Li, Jun ^{[1
]}

Li, Ruijun ^{[10
]}

Li, Xiaoping ^{[1
,2
]}

Li, Fei ^{[1
,2
,8
]}

Ren, Huahui ^{[1
]}

Huang, Yan ^{[1
]}

Peng, Yangqing ^{[1
,19
]}

Li, Guanglei ^{[1
]}

Wen, Bo ^{[1
,2
]}

Dong, Bo ^{[1
]}

Chen, Ji-Yan ^{[4
]}

Geng, Qing-Shan ^{[4
]}

Zhang, Zhi-Wei ^{[4
]}

Yang, Huanming ^{[1
,2
,11
]}

Wang, Jian ^{[1
,2
,11
]}

Wang, Jun ^{[1
,12
,20
]}

Zhang, Xuan ^{[13
,14
]}

Madsen, Lise ^{[1
,2
,7
,15
]}

Brix, Susanne ^{[16
]}

Ning, Guang ^{[17
]}

Xu, Xun ^{[1
,2
]}

Liu, Xin ^{[1
,2
]}

Hou, Yong ^{[1
,2
]}

Jia, Huijue ^{[1
,2
,3
,12
]}

He, Kunlun ^{[10
]}

Kristiansen, Karsten ^{[1
,2
,7
]}

机构：

[1] BGI Shenzhen, Shenzhen 518083, Peoples R China

[2] China Natl Genebank, Shenzhen 518120, Peoples R China

[3] BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen 518083, Peoples R China

[4] Guangdong Cardiovasc Inst, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangzhou 510080, Guangdong, Peoples R China

[5] Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangzhou 510080, Guangdong, Peoples R China

[6] Shenzhen Engn Lab Detect & Intervent Human Intest, Shenzhen 518083, Peoples R China

[7] Univ Copenhagen, Lab Genom & Mol Biomed, Dept Biol, Univ Pk 13, DK-2100 Copenhagen, Denmark

[8] Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen 518083, Peoples R China

[9] South China Univ Technol, Sch Biosci & Biotechnol, Guangzhou 510006, Guangdong, Peoples R China

[10] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Precis Med Chron Heart Failure, Beijing 100853, Peoples R China

[11] James D Watson Inst Genome Sci, Hangzhou 310000, Zhejiang, Peoples R China

[12] Macau Univ Sci & Technol, Macau 999078, Peoples R China

[13] Chinese Acad Med Sci, Dept Rheumatol & Clin Immunol, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China

[14] Peking Union Med Coll, Beijing 100730, Peoples R China

[15] NIFES, Natl Inst Nutr & Seafood Res, Postboks 2029, N-5817 Bergen, Norway

[16] Tech Univ Denmark, Dept Biotechnol & Biomed, DK-2800 Lyngby, Denmark

[17] Shanghai Jiao Tong Univ, Sch Med,Dept Endocrinol & Metab, Ruijin Hosp,Natl Clin Res Ctr Metab Dis,State Key, Shanghai Inst Endocrine & Metab Dis,Shanghai Clin, Shanghai 200025, Peoples R China

[18] Shandong Univ, Sch Stomatol, Dept Human Microbiome, Shandong Prov Key Lab Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China

[19] Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63110 USA

[20] ICarbonX, Shenzhen 518053, Peoples R China

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

关键词：

METAGENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; REDUNDANCY ANALYSIS; L-CARNITINE; METABOLISM; TRIMETHYLAMINE; DIVERSITY; DIET; PHOSPHATIDYLCHOLINE; INTERVENTION;

D O I：

10.1038/s41467-017-00900-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.

引用

页数：12

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