Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction

被引：106

作者：

Shin, MH ^{[1
]}

Hong, MK

Kim, WS

Lee, YJ

Jeoung, YC

机构：

[1] Busan Reg Food & Drug Adm, Pusan 608829, South Korea

[2] Korea Food & Drug Adm, Dept Food Evaluat, Seoul 122704, South Korea

来源：

FOOD ADDITIVES AND CONTAMINANTS | 2003年 / 20卷 / 09期

关键词：

sildenafil; homosildenafil; erectile dysfunction; NMR; HPLC;

D O I：

10.1080/0265203031000121455

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new analogue of sildenafil was discovered to have been added illegally to a functional food marketed for penile erectile dysfunction. The structure of the analogue was established by various NMR spectroscopic techniques (including DEPT, COSY, TOCSY, HMQC, HMBC). Because of the addition of a methylene group to sildenafil, the main ingredient of Viagra(R), it was given the name homosildenafil, and this has never been reported previously. An analytical method using HPLC was proposed. Homosildenafil was added as a new inspection item and other foods have since been discovered to contain it.

引用

页码：793 / 796

页数：4