B-cell depletion in the treatment of rheumatoid arthritis

被引：0
|
作者：
Feist, E [1 ]
Burmester, GR [1 ]
Dörner, T [1 ]
机构：
[1] Humboldt Univ, Univ Klinikum Charite, Med Klin, Schwerpunkt Rheumatol & Klin Immunol, D-10117 Berlin, Germany
来源：
ZEITSCHRIFT FUR RHEUMATOLOGIE | 2003年 / 62卷 / 04期
关键词：
B-cell depletion; anti-CD20-antibody; rituximab; rheuamtoid arthritis; MONOCLONAL-ANTIBODY; RITUXIMAB THERAPY; MECHANISMS; EFFICACY; DISEASE;
D O I：
10.1007/s00393-003-0539-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
New strategies including the blockade of TNFalpha showed excellent therapeutic effects even in so far refractory rheumatic diseases. Moreover, these approaches provided us with important informations about the pathogenic role of the mediators involved and distinct autoimmune cellular subsets. Here, we discuss recent data of a temporary B cell depletion using a monoclonal anti-CD20 antibody in the therapeutic arsenal of rheumatoid arthritis.
引用
收藏
页码：361 / 366
页数：6
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