Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities

被引：25

作者：

Vishwakarma, Niraj Kumar ^{[1
]}

Patel, Vijay Kumar ^{[1
]}

Hira, Sumit Kumar ^{[2
]}

Ramesh, K. ^{[1
,3
]}

Srivastava, Prateek ^{[1
,2
]}

Mitra, Kheyanath ^{[1
]}

Singh, Shikha ^{[1
]}

Chattopadhyay, Dipankar ^{[4
]}

Maiti, Pralay ^{[5
]}

Misra, Nira ^{[3
]}

Manna, Partha Pratim ^{[2
]}

Ray, Biswajit ^{[1
]}

机构：

[1] Banaras Hindu Univ, Fac Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

[2] Banaras Hindu Univ, Fac Sci, Dept Zool, Varanasi 221005, Uttar Pradesh, India

[3] Banaras Hindu Univ, Indian Inst Technol, Sch Biomed Engn, Varanasi 221005, Uttar Pradesh, India

[4] Univ Calcutta, Dept Polymer Sci & Technol, Kolkata 700009, India

[5] Banaras Hindu Univ, Indian Inst Technol, Sch Mat Sci & Technol, Varanasi 221005, Uttar Pradesh, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 20期

关键词：

CONTROLLED RADICAL POLYMERIZATION; MEDIATED RAFT POLYMERIZATION; HOST-GUEST INTERACTIONS; N-VINYLPYRROLIDONE; BLOCK-COPOLYMERS; CLICK-CHEMISTRY; MICELLES; POLYMERS; GLYCOL); SYSTEMS;

D O I：

10.1039/c4ra15359f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tadpole-shaped beta-cyclodextrin-tagged poly(N-vinylpyrrolidone) (beta-CD-PNVP) has been synthesised via the click reaction of alkyne-terminated PNVP and azide-functionalized beta-CD. The formed polymer is characterized by H-1 NMR, FTIR, and TGA study. The complexing ability of such a polymer with phenolphthalein is considerably lower with respect to that with beta-CD alone. Doxorubicin (DOX)-loaded beta-CD-PNVP (DOX-beta-CD-PNVP) exhibits higher tumoricidal activity against a panel of tumor cell lines derived from sarcoma (U2-OS) and carcinomas (MCF-7 and HEPG2), causing significant lysis of tumor cells compared to free DOX. The formulation also demonstrates significantly higher uptake by the tumor cells and enhances apoptosis compared to free DOX.

引用

页码：15547 / 15558

页数：12

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