Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

被引：52

作者：

Kiseleva, Elena ^{[1
]}

Kirillin, Mikhail ^{[2
,5
]}

Feldchtein, Felix ^{[1
]}

Vitkin, Alex ^{[1
,3
,4
]}

Sergeeva, Ekaterina ^{[2
,5
]}

Zagaynova, Elena ^{[1
]}

Streltzova, Olga ^{[1
]}

Shakhov, Boris ^{[1
]}

Gubarkova, Ekaterina ^{[1
]}

Gladkova, Natalia ^{[1
]}

机构：

[1] Nizhny Novgorod State Med Acad, Nizhnii Novgorod 603000, Russia

[2] RAS, Inst Appl Phys, Nizhnii Novgorod 603950, Russia

[3] Univ Toronto, Dept Med Biophys & Radiat Oncol, Toronto, ON M5G 2M9, Canada

[4] Univ Hlth Network, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

[5] NI Lobachevsky State Univ Nizhny Novgorod, Nizhnii Novgorod 603950, Russia

来源：

BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 04期

关键词：

FLUORESCENCE CYSTOSCOPY; BIOLOGICAL TISSUE; COLLAGEN; INFLAMMATION; CANCER;

D O I：

10.1364/BOE.6.001464

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is thus demonstrated in vivo. (C) 2015 Optical Society of America

引用

页码：1464 / 1476

页数：13

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