Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

被引：52

作者：

Kiseleva, Elena ^{[1
]}

Kirillin, Mikhail ^{[2
,5
]}

Feldchtein, Felix ^{[1
]}

Vitkin, Alex ^{[1
,3
,4
]}

Sergeeva, Ekaterina ^{[2
,5
]}

Zagaynova, Elena ^{[1
]}

Streltzova, Olga ^{[1
]}

Shakhov, Boris ^{[1
]}

Gubarkova, Ekaterina ^{[1
]}

Gladkova, Natalia ^{[1
]}

机构：

[1] Nizhny Novgorod State Med Acad, Nizhnii Novgorod 603000, Russia

[2] RAS, Inst Appl Phys, Nizhnii Novgorod 603950, Russia

[3] Univ Toronto, Dept Med Biophys & Radiat Oncol, Toronto, ON M5G 2M9, Canada

[4] Univ Hlth Network, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

[5] NI Lobachevsky State Univ Nizhny Novgorod, Nizhnii Novgorod 603950, Russia

来源：

BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 04期

关键词：

FLUORESCENCE CYSTOSCOPY; BIOLOGICAL TISSUE; COLLAGEN; INFLAMMATION; CANCER;

D O I：

10.1364/BOE.6.001464

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is thus demonstrated in vivo. (C) 2015 Optical Society of America

引用

页码：1464 / 1476

页数：13

共 35 条

[1]

American Cancer Society, 2014, CANC FACTS FIG 2014

[2]

Belinson S., 2009, 25 INT PAP C

[3]

Cheng L., 2012, Bladder Pathology

[4] ARE THE POLARIZATION COLORS OF PICROSIRIUS RED-STAINED COLLAGEN DETERMINED ONLY BY THE DIAMETER OF THE FIBERS [J].

DAYAN, D ;

HISS, Y ;

HIRSHBERG, A ;

BUBIS, JJ ;

WOLMAN, M .

HISTOCHEMISTRY, 1989, 93 (01) :27-29

[5] Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography [J].

deBoer, JF ;

Milner, TE ;

vanGemert, MJC ;

Nelson, JS .

OPTICS LETTERS, 1997, 22 (12) :934-936

[6] Molecular analysis of collagens in bladder fibrosis [J].

Deveaud, CM ;

Macarak, EJ ;

Kucich, U ;

Ewalt, DH ;

Abrams, WR ;

Howard, PS .

JOURNAL OF UROLOGY, 1998, 160 (04) :1518-1527

[7]

Feldchtein F. I., 2010, Polarization-sensitive common path optical coherence reflectometry/tomography device, Patent No. [7,728,985 B2, 7728985]

[8]

Feldchtein FI, 2002, HANDBOOK OF OPTICAL COHERENCE TOMOGRAPHY, P125

[9]

Ganganna Kokila, 2012, J Oral Maxillofac Pathol, V16, P162, DOI 10.4103/0973-029X.98446

[10] Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT) [J].

Giattina, SD ;

Courtney, BK ;

Herz, PR ;

Harman, M ;

Shortkroff, S ;

Stamper, DL ;

Liu, B ;

Fujimoto, JG ;

Brezinski, ME .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2006, 107 (03) :400-409

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