A Presynaptic Liquid Phase Unlocks the Vesicle Cluster

被引：7

作者：

Wang, Shan Shan H. ^{[1
]}

Kaeser, Pascal S. ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USA

来源：

TRENDS IN NEUROSCIENCES | 2018年 / 41卷 / 11期

关键词：

SYNAPTIC VESICLES; ACTIVE ZONE; SYNAPSIN;

D O I：

10.1016/j.tins.2018.07.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

How are synaptic vesicles tied together in a nerve terminal? A recent study by Milovanovic and colleagues offers a new mechanism for this old and important problem: synapsin proteins establish a liquid phase that clusters vesicles. Liquid-liquid phase separation provides a fluid-like state that accommodates the dynamic demands of presynaptic vesicle traffic.

引用

页码：772 / 774

页数：4

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