Dual-action platinum(II) Schiff base complexes: Photocytotoxicity and cellular imaging

被引：18
作者：
Banerjee, Samya [1 ]
Capper, Miles S. [1 ]
Clarkson, Guy J. [1 ]
Huang, Huaiyi [1 ,2 ]
Sadler, Peter J. [1 ]
机构：
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[2] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Guangdong, Peoples R China
来源：
POLYHEDRON | 2019年 / 172卷
基金：
英国工程与自然科学研究理事会;
关键词：
Platinum(II); Schiff base; Photocytotoxicity; Cellular imaging; Singlet oxygen; TRANSITION-METAL-COMPLEXES; PHOTODYNAMIC THERAPY; POLYPYRIDYL COMPLEXES; PT(II) COMPLEXES; PHOTOSENSITIZERS; EFFICIENT; DELIVERY;
D O I：
10.1016/j.poly.2019.04.024
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Nine photo-stable Pt(II) Schiff base complexes [Pt(O<^>N<^>N<^>O)] (Pt1-Pt9) containing tetradentate salicylaldimine chelating ligands have been synthesized and characterized as potential photosensitisers for photodynamic therapy (PDT). The effects of electron-withdrawing versus electron-donating substituents on their electronic spectral properties are investigated. Pt1-Pt9 show broad absorption bands between 400-600 nm, which makes them useful for green-light photodynamic therapy. The complexes showed intense phosphorescence with emission maxima at ca. 625 nm. This emission was used to track their cellular localization in cancer cells. Confocal cellular imaging showed that the complexes localized mostly in the cytoplasm. In the dark, the complexes were non-toxic to A549 human lung cancer cells, but exhibited high photo-toxicity upon low-dose green light (520 nm, 7.02 J/cm(2)) irradiation via photo-induced singlet oxygen generation. Thus, these photoactive Pt(II) complexes have the potential to overcome the problem of drug resistance and side effects of current clinical Pt(II) drugs, and to act as both theranostic as well as therapeutic agents. (C) 2019 The Authors. Published by Elsevier Ltd.
引用
收藏
页码：157 / 166
页数：10
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