Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy

被引：39

作者：

Chue-Sang, Joseph ^{[1
]}

Holness, Nola ^{[2
]}

Gonzalez, Mariacarla ^{[1
]}

Greaves, Joan ^{[3
]}

Saytashev, Ilyas ^{[4
]}

Stoff, Susan ^{[1
]}

Gandjbakhche, Amir ^{[5
]}

Chernomordik, Viktor V. ^{[5
]}

Burkett, Gene ^{[6
]}

Ramella-Roman, Jessica C. ^{[1
,4
]}

机构：

[1] Florida Int Univ, Dept Biomed Engn, Miami, FL 33199 USA

[2] Florida Int Univ, Nicole Wertheim Coll Nursing & Hlth Sci, Miami, FL 33199 USA

[3] Jackson Mem Hosp, Holtz Childrens Hosp, Miami, FL 33136 USA

[4] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL 33199 USA

[5] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Rockville, MD USA

[6] Univ Miami, Dept Obstet & Gynecol, Leonard Miller Sch Med, Miami, FL USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2018年 / 23卷 / 12期

关键词：

anisotropy; birefringence; collagen; Mueller matrix; cervix; colposcopy; PRETERM BIRTH; FLUORESCENCE; GESTATION; PREGNANCY;

D O I：

10.1117/1.JBO.23.12.121605

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Annually, about 15 million preterm infants are born in the world. Of these, due to complications resulting from their premature birth, about 1 million would die before the age of five. Since the high incidence of preterm birth (PTB) is partially due to the lack of effective diagnostic modalities, methodologies are needed to determine risk of PTB. We propose a noninvasive tool based on polarized light imaging aimed at measuring the organization of collagen in the cervix. Cervical collagen has been shown to remodel with the approach of parturition. We used a full-field Mueller matrix polarimetric colposcope to assess and compare cervical collagen content and structure in nonpregnant and pregnant women in vivo. Local collagen directional azimuth was used and a total of eight cervices were imaged. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

引用

页数：9

共 46 条

[1] Cervical Softening During Pregnancy: Regulated Changes in Collagen Cross-Linking and Composition of Matricellular Proteins in the Mouse [J].