Excess of weight: is it a modifiable predictive and prognostic factor in locally advanced rectal cancer?

被引:0
作者
De Felice, F. [1 ]
Musio, D. [1 ]
Magnante, A. L. [1 ]
Bulzonetti, N. [1 ]
Tombolini, V. [1 ,2 ]
机构
[1] Sapienza Univ Rome, Dept Radiotherapy, Policlin Umberto I, Rome, Italy
[2] Spencer Lorillard Fdn Rome, Rome, Italy
关键词
Rectal cancer; BMI; Obesity; Radiotherapy; Chemotherapy; Surgery; BODY-MASS INDEX; COLORECTAL-CANCER; VISCERAL OBESITY; OUTCOMES; MORTALITY; IMPACT;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
OBJECTIVE: To evaluate the relationship between body mass index (BMI) and rates of treatment tolerance and clinical outcomes in patients with locally advanced rectal cancer treated with a multimodality approach. PATIENTS AND METHODS: This study was conducted on 56 patients with histologically proven rectal adenocarcinoma, staged T3-4, and/or node-positive tumor, which underwent intensified radiochemotherapy (RT-CHT) treatment before surgery. We calculated adiposity indices and analyzed their influence on treatment tolerance and clinical outcomes. RESULTS: Distribution of the 56 patients according to BMI was BMI <25 kg/m(2) (n = 19; 33.9%), BMI 25-29 kg/m(2) (n = 29; 51.8%) and BMI = 30 kg/m(2) (n = 8; 14.3%). BMI had no significant influence on neo-adjuvant treatment-related toxicity. With a median follow-up of 23 months (range 11-47), the 2-year survival was 85.7%. We did not observe any significant difference among the three BMI categories for any of the outcomes. CONCLUSIONS: This study suggested no evident links between overweight and survival in patients with locally advanced rectal carcinoma treated with neo-adjuvant RT-CHT. Overweight patients tolerate treatment as normal-weight patients.
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收藏
页码:4606 / 4612
页数:7
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