Circadian dimension and severity of depression

被引:44
作者
Courtet, Philippe [1 ]
Olie, Emilie [1 ]
机构
[1] Univ Montpellier, CHRU Montpellier, INSERM, U1061, F-34059 Montpellier, France
关键词
Diurnal mood variation; Circadian rhythms; Clock genes; Biomarkers; Depression; Antidepressants; Agomelatine; DIURNAL MOOD VARIATION; CLOCK GENES; MORNINGNESS-EVENINGNESS; ANTIDEPRESSANT EFFICACY; TREATMENT ALTERNATIVES; BODY-TEMPERATURE; DISORDER; SLEEP; AGOMELATINE; RHYTHMS;
D O I
10.1016/j.euroneuro.2012.07.009
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The cyclic nature of depressive illness, disturbance of diurnal mood variations, and disturbed sleep-wake and physiological rhythms all suggest that dysfunction of the circadian time-keeping system may underlie the pathophysiology of depression. Circadian misalignment of the phase-delayed type appears to be the most common shift in unipolar disorder patients and misalignment between the timing of steep and the pacemaker is correlated with depressive symptom severity. Profiles of diurnal mood variation are associated with risks of depression severity and may predict response to treatments. As circadian disturbances are at the core of depression, normalizing circadian rhythm may be a fruitful avenue for new therapeutic targets in depression. The innovative antidepressant agomelatine possesses resynchronizing properties that may be related to its original profile and offers an opportunity to achieve our goals in treating depressed people. (C) 2012 Elsevier B.V. and ECNP. All rights reserved.
引用
收藏
页码:S476 / S481
页数:6
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