Treatment of ARDS

被引：143

作者：

Brower, RG

Ware, LB

Berthiaume, Y

Matthay, MA

机构：

[1] Univ Calif San Francisco, Inst Cardiovasc Res, San Francisco, CA 94143 USA

[2] Univ Montreal, Montreal, PQ, Canada

[3] Johns Hopkins Univ, Baltimore, MD USA

来源：

CHEST | 2001年 / 120卷 / 04期

关键词：

acute lung injury; mechanical ventilation; pulmonary edema; ventilator-associated lung injury;

D O I：

10.1378/chest.120.4.1347

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Improved understanding of the pathogenesis of acute lung injury (ALI)/ARDS has led to important advances in the treatment of ALI/ARDS, particularly in the area of ventilator-associated lung injury. Standard supportive care for ALI/ARDS should now include a protective ventilatory strategy ninth low tidal volume ventilation by the protocol developed by the National Institutes of Health ARDS Network. Further refinements of the protocol for mechanical ventilation hill occur as current and future clinical trials are completed. In addition, novel modes of mechanical ventilation are being studied and may augment standard therapy in the future. Although results of anti-inflammatory strategies have been disappointing in clinical trials, further trials are underway to test the efficacy of late corticosteroids and other approaches to modulation of inflammation in ALI/ARDS.

引用

页码：1347 / 1367

页数：21

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