Pathogenesis and management of pruritus in cholestatic liver disease

被引：48
作者：
Imam, Mohamad H. [1 ]
Gossard, Andrea A. [1 ]
Sinakos, Emmanouil [1 ]
Lindor, Keith D. [1 ]
机构：
[1] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2012年 / 27卷 / 07期
关键词：
cholestatic; itch; liver; pruritus; PRIMARY BILIARY-CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; URSODEOXYCHOLIC ACID THERAPY; RANDOMIZED-CONTROLLED-TRIALS; PRIMARY BILLARY CIRRHOSIS; MU-OPIOID RECEPTORS; SERUM BILE-ACIDS; INTRAHEPATIC CHOLESTASIS; DOUBLE-BLIND; HUMAN-SKIN;
D O I：
10.1111/j.1440-1746.2012.07109.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis and intrahepatic cholestasis of pregnancy commonly complain of pruritus. The underlying pathogenesis remains obscure with several mediators possibly playing an important role; these include lysophosphatidic acid, bile salts, opioids, histamine and progesterone metabolites. We describe in this review novel insights into the pathogenesis and management of pruritus in patients with cholestasis.
引用
收藏
页码：1150 / 1158
页数：9
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