Translational genomics: The challenge of developing cancer biomarkers

被引：78

作者：

Brooks, James D. ^{[1
]}

机构：

[1] Stanford Univ, Dept Urol, Stanford, CA 94305 USA

来源：

GENOME RESEARCH | 2012年 / 22卷 / 02期

关键词：

PROSTATE-SPECIFIC ANTIGEN; CELL LUNG-CANCER; PROMOTER HYPERMETHYLATION; COLORECTAL-CANCER; MULTIPLE GENES; METHYLATION; DNA; GEFITINIB; MORTALITY; URINE;

D O I：

10.1101/gr.124347.111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Early detection and definitive treatment of cancer have been shown to decrease death and suffering in epidemiologic and intervention studies. Application of genomic approaches to many malignancies has produced thousands of candidate biomarkers for detection and prognostication, yet very few have become established in clinical practice. Fundamental issues related to tumor heterogeneity, cancer progression, natural history, and biomarker performance have provided challenges to biomarker development. Technical issues in biomarker assay detection limits, specificity, clinical deployment, and regulation have also slowed progress. The recent emergence of biomarkers and molecular imaging strategies for treatment selection and monitoring demonstrates the promise of cancer biomarkers. Organized efforts by interdisciplinary teams will spur progress in cancer diagnostics.

引用

页码：183 / 187

页数：5

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