Translational genomics: The challenge of developing cancer biomarkers

被引：75
作者：
Brooks, James D. [1 ]
机构：
[1] Stanford Univ, Dept Urol, Stanford, CA 94305 USA
来源：
GENOME RESEARCH | 2012年 / 22卷 / 02期
关键词：
PROSTATE-SPECIFIC ANTIGEN; CELL LUNG-CANCER; PROMOTER HYPERMETHYLATION; COLORECTAL-CANCER; MULTIPLE GENES; METHYLATION; DNA; GEFITINIB; MORTALITY; URINE;
D O I：
10.1101/gr.124347.111
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Early detection and definitive treatment of cancer have been shown to decrease death and suffering in epidemiologic and intervention studies. Application of genomic approaches to many malignancies has produced thousands of candidate biomarkers for detection and prognostication, yet very few have become established in clinical practice. Fundamental issues related to tumor heterogeneity, cancer progression, natural history, and biomarker performance have provided challenges to biomarker development. Technical issues in biomarker assay detection limits, specificity, clinical deployment, and regulation have also slowed progress. The recent emergence of biomarkers and molecular imaging strategies for treatment selection and monitoring demonstrates the promise of cancer biomarkers. Organized efforts by interdisciplinary teams will spur progress in cancer diagnostics.
引用
收藏
页码：183 / 187
页数：5
相关论文
共 52 条
  • [1] Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
    Aberle, Denise R.
    Adams, Amanda M.
    Berg, Christine D.
    Black, William C.
    Clapp, Jonathan D.
    Fagerstrom, Richard M.
    Gareen, Ilana F.
    Gatsonis, Constantine
    Marcus, Pamela M.
    Sicks, JoRean D.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) : 395 - 409
  • [2] Mortality Results from a Randomized Prostate-Cancer Screening Trial
    Andriole, Gerald L.
    Grubb, Robert L., III
    Buys, Saundra S.
    Chia, David
    Church, Timothy R.
    Fouad, Mona N.
    Gelmann, Edward P.
    Kvale, Paul A.
    Reding, Douglas J.
    Weissfeld, Joel L.
    Yokochi, Lance A.
    Crawford, E. David
    O'Brien, Barbara
    Clapp, Jonathan D.
    Rathmell, Joshua M.
    Riley, Thomas L.
    Hayes, Richard B.
    Kramer, Barnett S.
    Izmirlian, Grant
    Miller, Anthony B.
    Pinsky, Paul F.
    Prorok, Philip C.
    Gohagan, John K.
    Berg, Christine D.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (13) : 1310 - 1319
  • [3] Computed tomography screening and lung cancer outcomes
    Bach, Peter B.
    Jett, James R.
    Pastorino, Ugo
    Tockman, Melvyn S.
    Swensen, Stephen J.
    Begg, Colin B.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (09): : 953 - 961
  • [4] Screening for Prostate Cancer - The Controversy That Refuses to Die
    Barry, Michael J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (13) : 1351 - 1354
  • [5] Integrated genomic analyses of ovarian carcinoma
    Bell, D.
    Berchuck, A.
    Birrer, M.
    Chien, J.
    Cramer, D. W.
    Dao, F.
    Dhir, R.
    DiSaia, P.
    Gabra, H.
    Glenn, P.
    Godwin, A. K.
    Gross, J.
    Hartmann, L.
    Huang, M.
    Huntsman, D. G.
    Iacocca, M.
    Imielinski, M.
    Kalloger, S.
    Karlan, B. Y.
    Levine, D. A.
    Mills, G. B.
    Morrison, C.
    Mutch, D.
    Olvera, N.
    Orsulic, S.
    Park, K.
    Petrelli, N.
    Rabeno, B.
    Rader, J. S.
    Sikic, B. I.
    Smith-McCune, K.
    Sood, A. K.
    Bowtell, D.
    Penny, R.
    Testa, J. R.
    Chang, K.
    Dinh, H. H.
    Drummond, J. A.
    Fowler, G.
    Gunaratne, P.
    Hawes, A. C.
    Kovar, C. L.
    Lewis, L. R.
    Morgan, M. B.
    Newsham, I. F.
    Santibanez, J.
    Reid, J. G.
    Trevino, L. R.
    Wu, Y. -Q.
    Wang, M.
    [J]. NATURE, 2011, 474 (7353) : 609 - 615
  • [6] The genomic complexity of primary human prostate cancer
    Berger, Michael F.
    Lawrence, Michael S.
    Demichelis, Francesca
    Drier, Yotam
    Cibulskis, Kristian
    Sivachenko, Andrey Y.
    Sboner, Andrea
    Esgueva, Raquel
    Pflueger, Dorothee
    Sougnez, Carrie
    Onofrio, Robert
    Carter, Scott L.
    Park, Kyung
    Habegger, Lukas
    Ambrogio, Lauren
    Fennell, Timothy
    Parkin, Melissa
    Saksena, Gordon
    Voet, Douglas
    Ramos, Alex H.
    Pugh, Trevor J.
    Wilkinson, Jane
    Fisher, Sheila
    Winckler, Wendy
    Mahan, Scott
    Ardlie, Kristin
    Baldwin, Jennifer
    Simons, Jonathan W.
    Kitabayashi, Naoki
    MacDonald, Theresa Y.
    Kantoff, Philip W.
    Chin, Lynda
    Gabriel, Stacey B.
    Gerstein, Mark B.
    Golub, Todd R.
    Meyerson, Matthew
    Tewari, Ashutosh
    Lander, Eric S.
    Getz, Gad
    Rubin, Mark A.
    Garraway, Levi A.
    [J]. NATURE, 2011, 470 (7333) : 214 - 220
  • [7] The Preclinical Natural History of Serous Ovarian Cancer: Defining the Target for Early Detection
    Brown, Patrick O.
    Palmer, Chana
    [J]. PLOS MEDICINE, 2009, 6 (07)
  • [8] A Perspective on Cancer Cell Metastasis
    Chaffer, Christine L.
    Weinberg, Robert A.
    [J]. SCIENCE, 2011, 331 (6024) : 1559 - 1564
  • [9] Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene
    Chen, WD
    Han, ZJ
    Skoletsky, J
    Olson, J
    Sah, J
    Myeroff, L
    Platzer, P
    Lu, SL
    Dawson, D
    Willis, J
    Pretlow, TR
    Lutterbaugh, J
    Kasturi, L
    Willson, JKV
    Rao, JS
    Shuber, A
    Markowitz, SD
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (15): : 1124 - 1132
  • [10] Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    Chin, L.
    Meyerson, M.
    Aldape, K.
    Bigner, D.
    Mikkelsen, T.
    VandenBerg, S.
    Kahn, A.
    Penny, R.
    Ferguson, M. L.
    Gerhard, D. S.
    Getz, G.
    Brennan, C.
    Taylor, B. S.
    Winckler, W.
    Park, P.
    Ladanyi, M.
    Hoadley, K. A.
    Verhaak, R. G. W.
    Hayes, D. N.
    Spellman, Paul T.
    Absher, D.
    Weir, B. A.
    Ding, L.
    Wheeler, D.
    Lawrence, M. S.
    Cibulskis, K.
    Mardis, E.
    Zhang, Jinghui
    Wilson, R. K.
    Donehower, L.
    Wheeler, D. A.
    Purdom, E.
    Wallis, J.
    Laird, P. W.
    Herman, J. G.
    Schuebel, K. E.
    Weisenberger, D. J.
    Baylin, S. B.
    Schultz, N.
    Yao, Jun
    Wiedemeyer, R.
    Weinstein, J.
    Sander, C.
    Gibbs, R. A.
    Gray, J.
    Kucherlapati, R.
    Lander, E. S.
    Myers, R. M.
    Perou, C. M.
    McLendon, Roger
    [J]. NATURE, 2008, 455 (7216) : 1061 - 1068
123456