Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

被引：131

作者：

Zhu, Jinge ^{[1
]}

DeLuca, Hector F. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 523卷 / 01期

关键词：

Cytochrome P450 enzymes; CYP27A1; CYP2R1; CYP2J2/3; CYP3A4; CYP2D25; CYP2C11; CYTOCHROME-P-450; CATALYZING; 25-HYDROXYLATION; RAT-LIVER; MOLECULAR-CLONING; MITOCHONDRIAL CYTOCHROME-P-450; 25-HYDROXYVITAMIN D-3; MESSENGER-RNA; D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; STEROL; 27-HYDROXYLASE; ALPHA-HYDROXYLASE;

D O I：

10.1016/j.abb.2012.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioactivation of vitamin D-3 involves 25-hydroxylation and subsequent 1 alpha-hydroxylation to produce 1 alpha,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], the active hormone. six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：30 / 36

页数：7

共 50 条

[41] De-orphanization of cytochrome P450 2R1 - A microsomal vitamin D 25-hydroxylase
Cheng, JB
Motola, DL
Mangelsdorf, DJ
Russell, DW
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (39) : 38084 - 38093
[42] Biochemical and structural characterization of CYP109A2, a vitamin D3 25-hydroxylase from Bacillus megaterium
Abdulmughni, Ammar
Jozwik, Ilona K.
Brill, Elisa
Hannemann, Frank
Thunnissen, Andy-Mark W. H.
Bernhardt, Rita
FEBS JOURNAL, 2017, 284 (22) : 3881 - 3894
[43] Vitamin D-Dependent Rickets Type 1B (25-Hydroxylase Deficiency): A Rare Condition or a Misdiagnosed Condition?
Molin, Arnaud
Wiedemann, Arnaud
Demers, Nick
Kaufmann, Martin
Do Cao, Jeremy
Mainard, Laurent
Dousset, Brigitte
Journeau, Pierre
Abeguile, Genevieve
Coudray, Nadia
Mittre, Herve
Richard, Nicolas
Weryha, Georges
Sorlin, Arthur
Jones, Glenville
Kottler, Marie-Laure
Feillet, Francois
JOURNAL OF BONE AND MINERAL RESEARCH, 2017, 32 (09) : 1893 - 1899
[44] Phenobarbital suppresses vitamin D3 25-hydroxylase expression:: A potential new mechanism for drug-induced osteomalacia
Hosseinpour, Fardin
Efolk, Maria
Norlin, Maria
Wikvall, Kjell
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 357 (03) : 603 - 607
[45] Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D
Roizen, Jeffrey D.
Long, Caela
Casella, Alex
O'Lear, Lauren
Caplan, Ilana
Lai, Meizan
Sasson, Issac
Singh, Ravinder
Makowski, Andrew J.
Simmons, Rebecca
Levine, Michael A.
JOURNAL OF BONE AND MINERAL RESEARCH, 2019, 34 (06) : 1068 - 1073
[46] CYP3A4 is a vitamin D-24- and 25-hydroxylase: Analysis of structure function by site-directed mutagenesis
Gupta, RP
He, YA
Patrick, KS
Halpert, JR
Bell, NH
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (02): : 1210 - 1219
[47] CLONING AND NUCLEOTIDE-SEQUENCE OF A BACTERIAL CYTOCHROME P-450(VD25) GENE ENCODING VITAMIN-D-3 25-HYDROXYLASE
KAWAUCHI, H
SASAKI, J
ADACHI, T
HANADA, K
BEPPU, T
HORINOUCHI, S
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1994, 1219 (01): : 179 - 183
[48] The steady state expression of the gene encoding the hepatic mitochondrial vitamin D-3 25-hydroxylase (CYP27) is not regulated by the vitamin D or calcium status.
Theodoropoulos, C
Demers, C
Neron, S
GasconBarre, M
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 : S393 - S393
[49] Porcine microsomal vitamin D3 25-hydroxylase (CYP2D25) -: Catalytic properties, tissue distribution, and comparison with human CYP2D6
Hosseinpour, F
Wikvall, K
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (44) : 34650 - 34655
[50] Assessing vitamin D metabolism - four decades of experience
Herrmann, Markus
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2023, 61 (05) : 880 - 894

← 1 2 3 4 5 →