Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

被引：131
|
作者：
Zhu, Jinge [1 ]
DeLuca, Hector F. [1 ]
机构：
[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 523卷 / 01期
关键词：
Cytochrome P450 enzymes; CYP27A1; CYP2R1; CYP2J2/3; CYP3A4; CYP2D25; CYP2C11; CYTOCHROME-P-450; CATALYZING; 25-HYDROXYLATION; RAT-LIVER; MOLECULAR-CLONING; MITOCHONDRIAL CYTOCHROME-P-450; 25-HYDROXYVITAMIN D-3; MESSENGER-RNA; D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; STEROL; 27-HYDROXYLASE; ALPHA-HYDROXYLASE;
D O I：
10.1016/j.abb.2012.01.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioactivation of vitamin D-3 involves 25-hydroxylation and subsequent 1 alpha-hydroxylation to produce 1 alpha,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], the active hormone. six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：30 / 36
页数：7
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