Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

被引：132

作者：

Zhu, Jinge ^{[1
]}

DeLuca, Hector F. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 523卷 / 01期

关键词：

Cytochrome P450 enzymes; CYP27A1; CYP2R1; CYP2J2/3; CYP3A4; CYP2D25; CYP2C11; CYTOCHROME-P-450; CATALYZING; 25-HYDROXYLATION; RAT-LIVER; MOLECULAR-CLONING; MITOCHONDRIAL CYTOCHROME-P-450; 25-HYDROXYVITAMIN D-3; MESSENGER-RNA; D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; STEROL; 27-HYDROXYLASE; ALPHA-HYDROXYLASE;

D O I：

10.1016/j.abb.2012.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioactivation of vitamin D-3 involves 25-hydroxylation and subsequent 1 alpha-hydroxylation to produce 1 alpha,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], the active hormone. six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：30 / 36

页数：7

共 110 条

[1] CHARACTERIZATION OF A FEMALE-SPECIFIC HEPATIC MITOCHONDRIAL CYTOCHROME-P-450 WHOSE STEADY-STATE LEVEL IS MODULATED BY TESTOSTERONE [J].