Tunable Degradation Rate and Favorable Bioactivity of Porous Calcium Sulfate Scaffolds by Introducing Nano-Hydroxyapatite

被引：6

作者：

Zhou, Jianhua ^{[1
]}

Yuan, Fulai ^{[2
]}

Peng, Shuping ^{[3
,4
]}

Xie, Hui ^{[5
]}

Wu, Ping ^{[6
]}

Feng, Pei ^{[1
]}

Gao, Chengde ^{[1
]}

Yang, Youwen ^{[1
,7
]}

Guo, Wang ^{[1
]}

Lai, Duan ^{[8
]}

Zhou, Zhiyang ^{[8
]}

Zhu, Xueling ^{[9
]}

Shuai, Cijun ^{[1
]}

机构：

[1] Cent S Univ, State Key Lab High Performance Complex Mfg, State Key Lab Powder Met, Changsha 410083, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Hlth Management Ctr, Changsha 410008, Hunan, Peoples R China

[3] Cent S Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Key Lab Carcinogenesis,Chinese Minist Hlth, Changsha 410078, Hunan, Peoples R China

[4] Cent S Univ, Canc Res Inst, Xiangya Hosp, Changsha 410078, Hunan, Peoples R China

[5] Cent S Univ, Xiangya Hosp, Mot Syst Injury Repair Res Ctr, Changsha 410078, Hunan, Peoples R China

[6] Xiangtan Univ, Coll Chem, Xiangtan 411105, Peoples R China

[7] Northwestern Polytech Univ, State Key Lab Solidificat Proc, Xian 710072, Peoples R China

[8] Hunan Farsoon High Technol Co Ltd, Changsha 410205, Hunan, Peoples R China

[9] Natl Univ Def Technol, Sch Humanities & Social Sci, Changsha 410074, Hunan, Peoples R China

来源：

APPLIED SCIENCES-BASEL | 2016年 / 6卷 / 12期

基金：

中国国家自然科学基金;

关键词：

selected laser sintering; porous scaffolds; degradation rate; pH environment; bioactivity; DRUG-DELIVERY; BONE REPAIR; NANOCOMPOSITE; ENHANCEMENT; FABRICATION; COMPOSITES; BEHAVIOR; CELLS;

D O I：

10.3390/app6120411

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The bone scaffolds should possess suitable physicochemical properties and osteogenic activities. In this study, porous calcium sulfate (CaSO4) scaffolds were fabricated successfully via selected laser sintering (SLS). Nano-hydroxyapatite (nHAp), a bioactive material with a low degradation rate, was introduced into CaSO4 scaffolds to overcome the overquick absorption. The results demonstrated that nHAp could not only control the degradation rate of scaffolds by adjusting their content, but also improve the pH environment by alleviating the acidification progress during the degradation of CaSO4 scaffolds. Moreover, the improved scaffolds were covered completely with the apatite spherulites in simulated body fluid (SBF), showing their favorable bioactivity. In addition, the compression strength and fracture toughness were distinctly enhanced, which could be ascribed to large specific area of nHAp and the corresponding stress transfer.

引用

页数：13

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