Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections

被引：1

作者：

de Dios Rosado, Juan ^{[1
]}

Rodriguez-Sosa, Miriam ^{[1
]}

机构：

[1] UNAM, Unidad Biomed, Fac Estudios Super Iztacala, Tlalnepantla 54090, Estado De Mexic, Mexico

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2011年 / 7卷 / 09期

关键词：

Macrophage migration inhibitory factor; Protozoan infections; Inflammatory response; Control of parasite infections; innate immune response; PLASMODIUM-FALCIPARUM MALARIA; JUVENILE IDIOPATHIC ARTHRITIS; TOLL-LIKE RECEPTOR-4; FREE-LIVING AMEBAS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; RAT CRESCENTIC GLOMERULONEPHRITIS; TRYPANOSOMA-CRUZI INFECTION; LEISHMANIA-MAJOR INFECTION; INNATE IMMUNE-RESPONSES; IN-VIVO BLOCKADE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mo), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-alpha, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections.

引用

页码：1239 / 1256

页数：18

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